Department of Dermatology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
Department of Dermatology, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2022 Jul 26;12(1):12735. doi: 10.1038/s41598-022-17096-0.
Behçet's disease (BD) is a chronic inflammatory disease. Low levels of plasma high-density lipoprotein cholesterol (HDL-C) are associated with Crohn's disease, another chronic inflammatory disease. However, the effects of low HDL-C levels on BD are unclear. We investigated the effects of HDL-C levels, and variability therein, on the risk for BD. We used the Korean National Health Insurance System database to identify 5,587,754 adults without a history of BD who underwent ≥ 3 medical examinations between 2010 and 2013. Mean HDL-C levels at each visit were used to calculate variability independent of the mean (VIM) and the coefficient of variation (CV). There were 676 new cases of BD (0.012%). The risk for BD was increased in participants with highly variable and low mean HDL-C levels. In a multivariate-adjusted model, the hazard ratios (95% confidence intervals) for BD incidence were 1.335 (1.058-1.684) in a high mean/high VIM group, 1.527 (1.211-1.925) in a low mean/low VIM group, and 2.096 (1.67-2.63) in a low mean/high VIM group compared to a high mean/low VIM group. Low mean HDL-C levels, and high variability therein, are independent risk factors for BD.
贝赫切特病（BD）是一种慢性炎症性疾病。 血浆高密度脂蛋白胆固醇（HDL-C）水平低与另一种慢性炎症性疾病克罗恩病有关。 然而，低 HDL-C 水平对 BD 的影响尚不清楚。 我们研究了 HDL-C 水平及其变异性对 BD 风险的影响。 我们使用韩国国家健康保险系统数据库，确定了 5587754 名没有 BD 病史的成年人，这些成年人在 2010 年至 2013 年间接受了≥3 次体检。每次就诊的平均 HDL-C 水平用于计算独立于平均值的变异性（VIM）和变异系数（CV）。 有 676 例新 BD 病例（0.012%）。 在具有高度可变和低平均 HDL-C 水平的参与者中，BD 的风险增加。 在多变量调整模型中，BD 发病率的危险比（95%置信区间）在高平均/高 VIM 组为 1.335（1.058-1.684），在低平均/低 VIM 组为 1.527（1.211-1.925），在低平均/高 VIM 组为 2.096（1.67-2.63）与高平均/低 VIM 组相比。 低平均 HDL-C 水平及其高度变异性是 BD 的独立危险因素。
