Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY 40202, USA.
Cells. 2022 Jul 18;11(14):2230. doi: 10.3390/cells11142230.
Excitable cells of the nervous and cardiovascular systems depend on an assortment of plasmalemmal potassium channels to control diverse cellular functions. Voltage-gated potassium (Kv) channels are central to the feedback control of membrane excitability in these processes due to their activation by depolarized membrane potentials permitting K efflux. Accordingly, Kv currents are differentially controlled not only by numerous cellular signaling paradigms that influence channel abundance and shape voltage sensitivity, but also by heteromeric configurations of channel complexes. In this context, we discuss the current knowledge related to how intracellular Kvβ proteins interacting with pore complexes of -related Kv1 channels may establish a modifiable link between excitability and metabolic state. Past studies in heterologous systems have indicated roles for Kvβ proteins in regulating channel stability, trafficking, subcellular targeting, and gating. More recent works identifying potential in vivo physiologic roles are considered in light of these earlier studies and key gaps in knowledge to be addressed by future research are described.
兴奋细胞的神经和心血管系统依赖于各种各样的质膜钾通道来控制不同的细胞功能。电压门控钾 (Kv) 通道是这些过程中膜兴奋性反馈控制的核心，因为它们被去极化的膜电位激活，允许 K 外流。因此，Kv 电流不仅受到许多影响通道丰度和电压敏感性的细胞信号传递模式的差异控制，还受到通道复合物的异源构型的控制。在这方面，我们讨论了与细胞内 Kvβ 蛋白与 -相关 Kv1 通道的孔复合物相互作用如何在兴奋性和代谢状态之间建立可调节联系的相关知识。在异源系统中的过去研究表明 Kvβ 蛋白在调节通道稳定性、运输、亚细胞定位和门控方面的作用。考虑到这些早期研究和未来研究需要解决的知识空白，最近确定潜在的体内生理作用的研究工作被认为具有重要意义。
