Castellucci M, Celona A, Bartels H, Steininger B, Benedetto V, Kaufmann P
Placenta. 1987 Jan-Feb;8(1):65-76. doi: 10.1016/0143-4004(87)90040-3.
Human chorionic villi from placentae collected during the first half of pregnancy were examined by light microscopy and transmission electron microscopy. In serial semithin sections mitoses of Hofbauer cells, as well as those of other cellular components of the villous stroma, were generally easily identified. In some cases, when the Hofbauer cells showed very few vacuoles, thin sections were helpful in differentiating this cell type from the fixed stromal cells. Hofbauer cells in mitotic division were not uncommon, but were irregularly distributed. Mitosis of the Hofbauer cells could be a mechanism involved in maintaining the permanent presence in the chorionic villi of cell subpopulations with different origins and functions. Another explanation for the mitotic division of these cells could be that they are a self-renewing population independent of fetal monocytes which appear later in gestation in chorionic villi. In addition, mitosis of the Hofbauer cells could allow a rapid increase in their numbers when required by the local microenvironment.
对妊娠前半期采集的胎盘组织中的人绒毛膜绒毛进行了光学显微镜和透射电子显微镜检查。在连续半薄切片中，霍夫鲍尔细胞以及绒毛间质其他细胞成分的有丝分裂通常很容易识别。在某些情况下，当霍夫鲍尔细胞的空泡很少时，薄切片有助于将这种细胞类型与固定的间质细胞区分开来。处于有丝分裂期的霍夫鲍尔细胞并不罕见，但分布不规则。霍夫鲍尔细胞的有丝分裂可能是一种机制，参与维持绒毛膜绒毛中具有不同起源和功能的细胞亚群的永久存在。这些细胞有丝分裂的另一种解释可能是，它们是一个自我更新的群体，独立于妊娠后期出现在绒毛膜绒毛中的胎儿单核细胞。此外，当局部微环境有需要时，霍夫鲍尔细胞的有丝分裂可以使其数量迅速增加。
