Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Toruń, Poland.
Department of Cardiology and Internal Diseases, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Toruń, Poland.
Int J Environ Res Public Health. 2022 Jul 15;19(14):8637. doi: 10.3390/ijerph19148637.
High-density lipoproteins (HDL) play an important role in the prevention of atherosclerosis. The aim of the study was to assess the relationship between serum HDL-C concentration and proinflammatory/prothrombic activation in coronary artery disease (CAD) patients. The study group included 27 acute myocardial infarction (AMI) patients and 30 stable angina pectoris (SA) patients. The control group consisted of 23 people without cardiac symptoms. In the AMI and SA groups, a lower HDL-C and a higher LDL-C/HDL-C index were observed. The SA patients had lower total cholesterol, LDL-C, sE-selectin ligand, as well as higher triglycerides and CD40 concentration in comparison with both the control and AMI groups. A higher von Willebrand Factor and intercellular adhesion molecule-1 were found in both study groups. Low HDL-C concentration in the CAD patients may intensify pro-inflammatory endothelial activation and prothrombotic processes. A low concentration of HDL-C and a high value of the LDL-C/HDL-C index seem to be better indices of atherogenic processes than the LDL-C concentration alone.
高密度脂蛋白（HDL）在预防动脉粥样硬化中起着重要作用。本研究旨在评估冠心病（CAD）患者血清 HDL-C 浓度与促炎/促血栓形成激活之间的关系。研究组包括 27 例急性心肌梗死（AMI）患者和 30 例稳定型心绞痛（SA）患者。对照组由 23 名无心脏症状的人组成。在 AMI 和 SA 组中，观察到 HDL-C 降低和 LDL-C/HDL-C 指数升高。与对照组和 AMI 组相比，SA 患者的总胆固醇、LDL-C、sE-选择素配体较低，而甘油三酯和 CD40 浓度较高。两个研究组的血管性血友病因子和细胞间黏附分子-1 均升高。CAD 患者的 HDL-C 浓度降低可能会加剧促炎内皮激活和促血栓形成过程。与 LDL-C 浓度单独相比，HDL-C 浓度低和 LDL-C/HDL-C 指数高似乎是动脉粥样硬化过程更好的指标。
