College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
Int J Mol Sci. 2022 Jul 11;23(14):7641. doi: 10.3390/ijms23147641.
Mammalian adipose tissue can be divided into white and brown adipose tissue based on its colour, location, and cellular structure. Certain conditions, such as sympathetic nerve excitement, can induce the white adipose adipocytes into a new type of adipocytes, known as beige adipocytes. The process, leading to the conversion of white adipocytes into beige adipocytes, is called white fat browning. The dynamic balance between white and beige adipocytes is closely related to the body's metabolic homeostasis. Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders. This article aimed to provide an overview of recent advances in understanding white fat browning and the role of BAT in lipid metabolism.
哺乳动物的脂肪组织可根据其颜色、位置和细胞结构分为白色脂肪组织和棕色脂肪组织。某些条件，如交感神经兴奋，可诱导白色脂肪细胞向一种新的脂肪细胞类型转化，称为米色脂肪细胞。导致白色脂肪细胞向米色脂肪细胞转化的过程称为白色脂肪棕色化。白色和米色脂肪细胞之间的动态平衡与机体的代谢稳态密切相关。研究白色脂肪棕色化的信号转导通路可能为肥胖症的治疗和缓解肥胖相关的糖脂代谢紊乱提供新的思路。本文旨在综述近年来对白色脂肪棕色化的认识以及棕色脂肪在脂代谢中的作用的研究进展。
