复杂钙化冠状动脉病变旋磨术后药物洗脱支架治疗患者代谢综合征与临床结局的关系
Relationship between Metabolic Syndrome and Clinical Outcome in Patients Treated with Drug-Eluting Stenting after Rotational Atherectomy for Complex Calcified Coronary Lesions.
作者信息
Hu Bin, Xiao Changbo, Wang Zhijian, Jia Dean, Yang Shiwei, Jia Shuo, Zhai Guangyao, Han Hongya, Xu Xiaohan, Shi Dongmei, Zhou Yujie
机构信息
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
出版信息
J Clin Med. 2022 Jul 19;11(14):4192. doi: 10.3390/jcm11144192.
BACKGROUND AND AIMS
although an association between metabolic syndrome (MS) and cardiovascular disease risk has been documented, the relationship in patients with complex calcified coronary lesions undergoing rotational atherectomy (RA) and drug-eluting stent(DES) insertion remains controversial. Here, the influence of MS on outcomes was assessed.
METHODS AND RESULTS
we retrospectively included 398 patients who underwent RA and DES insertion for complex calcified coronary lesions in our institution between June 2015 and January 2019. The modified Adult Treatment Plan III was used to diagnose MS. The endpoint was major adverse cardiovascular events (MACEs), comprising mortality from all causes, myocardial infarction, and target vessel revascularization (TVR). In all, 173 (43.5%) patients had MS. MS was significantly associated with MACE over the 28.32 ± 6.79-month follow-up period (HR 1.783, 95% CI from 1.122 to 2.833) even after adjustment for other possible confounders.
CONCLUSION
MS was frequently observed in patients treated with RA with DES insertion for complex calcified coronary lesions. MS independently predicted MACE in these patients.
背景与目的
尽管代谢综合征（MS）与心血管疾病风险之间的关联已有文献记载，但在接受旋磨术（RA）和药物洗脱支架（DES）植入的复杂钙化冠状动脉病变患者中，二者的关系仍存在争议。在此，我们评估了MS对预后的影响。
方法与结果
我们回顾性纳入了2015年6月至2019年1月期间在我院接受RA和DES植入治疗复杂钙化冠状动脉病变的398例患者。采用改良的成人治疗计划III来诊断MS。终点为主要不良心血管事件（MACE），包括全因死亡率、心肌梗死和靶血管血运重建（TVR）。共有173例（43.5%）患者患有MS。即使在对其他可能的混杂因素进行调整后，在28.32±6.79个月的随访期内，MS与MACE仍显著相关（HR 1.783，95%CI为1.122至2.833）。
结论
在接受RA和DES植入治疗复杂钙化冠状动脉病变的患者中，MS较为常见。MS可独立预测这些患者的MACE。
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