Roig-Soriano Xavier, Souto Eliana B, Elmsmari Firas, Garcia Maria Luisa, Espina Marta, Duran-Sindreu Fernando, Sánchez-López Elena, González Sánchez Jose Antonio
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal.
Pharmaceutics. 2022 Jul 21;14(7):1519. doi: 10.3390/pharmaceutics14071519.
Endodontic-related diseases constitute the fourth most expensive pathologies in industrialized countries. Specifically, endodontics is the part of dentistry focused on treating disorders of the dental pulp and its consequences. In order to treat these problems, especially endodontic infections, dental barriers and complex root canal anatomy should be overcome. This constitutes an unmet medical need since the rate of successful disinfection with the currently marketed drugs is around 85%. Therefore, nanoparticles constitute a suitable alternative in order to deliver active compounds effectively to the target site, increasing their therapeutic efficacy. Therefore, in the present review, an overview of dental anatomy and the barriers that should be overcome for effective disinfection will be summarized. In addition, the versatility of nanoparticles for drug delivery and their specific uses in dentistry are comprehensively discussed. Finally, the latest findings, potential applications and state of the art nanoparticles with special emphasis on biodegradable nanoparticles used for endodontic disinfection are also reviewed.
在工业化国家，牙髓病相关疾病是第四大高成本病理疾病。具体而言，牙髓病学是牙科的一个分支，专注于治疗牙髓疾病及其后果。为了治疗这些问题，尤其是牙髓感染，必须克服牙体屏障和复杂的根管解剖结构。这构成了一项未满足的医疗需求，因为目前市售药物的成功消毒率约为85%。因此，纳米颗粒是一种合适的选择，可有效将活性化合物输送到靶位点，提高其治疗效果。因此，在本综述中，将总结牙齿解剖结构以及有效消毒应克服的屏障的概述。此外，还全面讨论了纳米颗粒在药物递送方面的多功能性及其在牙科中的具体应用。最后，还综述了最新研究结果、潜在应用以及最先进的纳米颗粒，特别强调了用于牙髓消毒的可生物降解纳米颗粒。
