Badescu Bianca, Buda Valentina, Romanescu Mirabela, Lombrea Adelina, Danciu Corina, Dalleur Olivia, Dohou Angele Modupe, Dumitrascu Victor, Cretu Octavian, Licker Monica, Muntean Delia
Doctoral School, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Faculty of Pharmacy, "Victor Babeş" University of Medicine and Pharmacy, 2 Eftimie Murgu Street, 300041 Timisoara, Romania.
Plants (Basel). 2022 Jul 6;11(14):1789. doi: 10.3390/plants11141789.
The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of antimicrobial resistance (AMR). Nowadays, there is an urgent need for more potent, non-toxic and effective antimicrobial agents against MDR strains. In this regard, clinicians, pharmacists, microbiologists and the entire scientific community are encouraged to find alternative solutions in treating infectious diseases cause by these strains. In its "10 global issues to track in 2021", the World Health Organization (WHO) has made fighting drug resistance a priority. It has also issued a list of bacteria that are in urgent need for new ABs. Despite all available resources, researchers are unable to keep the pace of finding novel ABs in the face of emerging MDR strains. Traditional methods are increasingly becoming ineffective, so new approaches need to be considered. In this regard, the general tendency of turning towards natural alternatives has reinforced the interest in essential oils (EOs) as potent antimicrobial agents. Our present article aims to first review the main pathogens classified by WHO as critical in terms of current AMR. The next objective is to summarize the most important and up-to-date aspects of resistance mechanisms to classical antibiotic therapy and to compare them with the latest findings regarding the efficacy of alternative essential oil therapy.
多重耐药（MDR）病原体的出现已成为全球健康威胁，并在为许多感染提供充分且有效的治疗方面构成经济负担。这种大规模的担忧主要是由于抗生素（ABs）的不当使用而出现的，并导致了抗菌药物耐药性（AMR）的迅速蔓延。如今，迫切需要更有效、无毒且高效的抗MDR菌株的抗菌剂。在这方面，鼓励临床医生、药剂师、微生物学家和整个科学界寻找治疗由这些菌株引起的传染病的替代解决方案。世界卫生组织（WHO）在其“2021年需要关注的10个全球问题”中将对抗耐药性列为优先事项。它还发布了一份急需新型ABs的细菌清单。尽管有所有可用资源，但面对新出现的MDR菌株，研究人员仍无法跟上寻找新型ABs的步伐。传统方法越来越无效，因此需要考虑新的方法。在这方面，转向天然替代品的总体趋势增强了人们对作为有效抗菌剂的精油（EOs）的兴趣。我们目前的文章旨在首先回顾世界卫生组织根据当前AMR分类为关键的主要病原体。下一个目标是总结经典抗生素治疗耐药机制的最重要和最新方面，并将它们与替代精油治疗疗效的最新发现进行比较。
