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不同韩国燕麦（L.）品种幼苗生长时期相关的聚二十碳烯醇的比较分析及5'-单磷酸腺苷激活蛋白激酶（AMPK）激活筛选

Comparative Analysis of Policosanols Related to Growth Times from the Seedlings of Various Korean Oat ( L.) Cultivars and Screening for Adenosine 5'-Monophosphate-Activated Protein Kinase (AMPK) Activation.

作者信息

Lee Han-Gyeol, Woo So-Yeun, Ahn Hyung-Jae, Yang Ji-Yeong, Lee Mi-Ja, Kim Hyun-Young, Song Seung-Yeob, Lee Jin-Hwan, Seo Woo-Duck

机构信息

Crop Foundation Research Division, National Institute of Crop Science, Rural Development Administration, Jeollabuk-do, Wanju-gun 55365, Korea.

Division of Life Sciences, College of Natural Science, Jeonbuk National University, 567 Baekje-daero, Jeollabuk-do, Jeonju 54896, Korea.

出版信息

Plants (Basel). 2022 Jul 14;11(14):1844. doi: 10.3390/plants11141844.

DOI:10.3390/plants11141844
PMID:35890478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9323369/
Abstract

The objectives of this research were to evaluate the policosanol profiles and adenosine-5'-monophosphate-activated protein kinase (AMPK) properties in the seedlings of Korean oat ( L.) cultivars at different growth times. Nine policosanols in the silylated hexane extracts were detected using GC-MS and their contents showed considerable differences; specifically, hexacosanol (6) exhibited the highest composition, constituting 88-91% of the total average content. Moreover, the average hexacosanol (6) contents showed remarkable variations of 337.8 (5 days) → 416.8 (7 days) → 458.9 (9 days) → 490.0 (11 days) → 479.2 (13 days) → 427.0 mg/100 g (15 days). The seedlings collected at 11 days showed the highest average policosanol content (541.7 mg/100 g), with the lowest content being 383.4 mg/100 g after 5 days. Interestingly, policosanols from oat seedlings grown for 11 days induced the most prevalent phenotype of AMPK activation in HepG2 cells, indicating that policosanols are an excellent AMPK activator.

摘要

本研究的目的是评估不同生长时期韩国燕麦（L.）品种幼苗中的 policosanol 谱和 5'-单磷酸腺苷激活蛋白激酶（AMPK）特性。使用气相色谱-质谱联用仪（GC-MS）检测了硅烷化己烷提取物中的九种 policosanol，其含量显示出显著差异；具体而言，二十六烷醇（6）的含量最高，占总平均含量的 88-91%。此外，平均二十六烷醇（6）含量呈现出显著变化：337.8（5 天）→416.8（7 天）→458.9（9 天）→490.0（11 天）→479.2（13 天）→427.0 毫克/100 克（15 天）。在 11 天收集的幼苗显示出最高的平均 policosanol 含量（541.7 毫克/100 克），最低含量是 5 天后的 383.4 毫克/100 克。有趣的是，生长 11 天的燕麦幼苗中的 policosanol 在 HepG2 细胞中诱导了最普遍的 AMPK 激活表型，表明 policosanol 是一种出色的 AMPK 激活剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/4dbf9e255283/plants-11-01844-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/43fa34be09d3/plants-11-01844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/db11fdd673f3/plants-11-01844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/88da37a7dca8/plants-11-01844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/5843981056b9/plants-11-01844-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/4dbf9e255283/plants-11-01844-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/43fa34be09d3/plants-11-01844-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/db11fdd673f3/plants-11-01844-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/88da37a7dca8/plants-11-01844-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/5843981056b9/plants-11-01844-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60f7/9323369/4dbf9e255283/plants-11-01844-g005.jpg

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