Rabaan Ali A, Bakhrebah Muhammed A, Mutair Abbas Al, Alhumaid Saad, Al-Jishi Jumana M, AlSihati Jehad, Albayat Hawra, Alsheheri Ahmed, Aljeldah Mohammed, Garout Mohammed, Alfouzan Wadha A, Alhashem Yousef N, AlBahrani Salma, Alshamrani Saleh A, Alotaibi Sultan, AlRamadhan Abdullah A, Albasha Hanadi N, Hajissa Khalid, Temsah Mohamad-Hani
Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Vaccines (Basel). 2022 Jun 21;10(7):985. doi: 10.3390/vaccines10070985.
COVID-19, caused by SARS-CoV-2, is one of the longest viral pandemics in the history of mankind, which have caused millions of deaths globally and induced severe deformities in the survivals. For instance, fibrosis and cavities in the infected lungs of COVID-19 are some of the complications observed in infected patients post COVID-19 recovery. These health abnormalities, including is multiple organ failure-the most striking pathological features of COVID-19-have been linked with diverse distribution of ACE2 receptor. Additionally, several health complications reports were reported after administration of COVID-19 vaccines in healthy individuals, but clinical or molecular pathways causing such complications are not yet studied in detail. Thus, the present systematic review established the comparison of health complication noted in vaccinated and non-vaccinated individuals (COVID-19 infected patients) to identify the association between vaccination and the multiorgan failure based on the data obtained from case studies, research articles, clinical trials/Cohort based studies and review articles published between 2020-2022. This review also includes the biological rationale behind the COVID-19 infection and its subsequent symptoms and effects including multiorgan failure. In addition, multisystem inflammatory syndrome (MIS) has been informed in individuals post vaccination that resulted in multiorgan failure but, no direct correlation of vaccination with MIS has been established. Similarly, hemophagocytic lymphohistiocytosis (HLH) also noted to cause multiorgan failure in some individuals following full vaccination. Furthermore, severe complications were recorded in elderly patients (+40 years of age), indicates that older age individuals are higher risk by COVID-19 and post vaccination, but available literature is not sufficient to comply with any conclusive statements on relationship between vaccination and multiorgan failure.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）是人类历史上持续时间最长的病毒大流行之一，它在全球造成了数百万人死亡，并使幸存者出现严重畸形。例如，COVID-19感染肺部的纤维化和空洞是COVID-19康复后感染患者中观察到的一些并发症。这些健康异常情况，包括多器官功能衰竭（COVID-19最显著的病理特征），与血管紧张素转换酶2（ACE2）受体的不同分布有关。此外，在健康个体接种COVID-19疫苗后也报告了一些健康并发症，但导致这些并发症的临床或分子途径尚未得到详细研究。因此，本系统综述基于2020年至2022年发表的病例研究、研究文章、临床试验/队列研究和综述文章中的数据，对接种疫苗和未接种疫苗的个体（COVID-19感染患者）中出现的健康并发症进行了比较，以确定疫苗接种与多器官功能衰竭之间的关联。本综述还包括了COVID-19感染及其后续症状和影响（包括多器官功能衰竭）背后的生物学原理。此外，在接种疫苗后的个体中报告了多系统炎症综合征（MIS），其导致了多器官功能衰竭，但尚未确定疫苗接种与MIS之间的直接关联。同样，噬血细胞性淋巴组织细胞增生症（HLH）在一些个体完全接种疫苗后也被发现会导致多器官功能衰竭。此外，老年患者（40岁以上）出现了严重并发症，这表明老年个体感染COVID-19和接种疫苗后的风险更高，但现有文献不足以就疫苗接种与多器官功能衰竭之间的关系作出任何结论性陈述。
