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Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of β-hydroxybutyrate: implications in cardioprotection and aging.

作者信息

Sadoshima Junichi

机构信息

Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA.

出版信息

J Cardiovasc Aging. 2022 Jul;2(3). doi: 10.20517/jca.2022.24. Epub 2022 Jul 4.

DOI:10.20517/jca.2022.24
PMID:35891705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9311383/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b929/9311383/fd9e293c6836/nihms-1821086-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b929/9311383/fd9e293c6836/nihms-1821086-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b929/9311383/fd9e293c6836/nihms-1821086-f0001.jpg

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本文引用的文献

1
Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling.禁食通过酮体信号诱导肌肉干细胞进入高度抵抗性的深度静止状态。
Cell Metab. 2022 Jun 7;34(6):902-918.e6. doi: 10.1016/j.cmet.2022.04.012. Epub 2022 May 17.
2
Molecular mechanisms of dietary restriction promoting health and longevity.饮食限制促进健康和长寿的分子机制。
Nat Rev Mol Cell Biol. 2022 Jan;23(1):56-73. doi: 10.1038/s41580-021-00411-4. Epub 2021 Sep 13.
3
Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator.
酮体β-羟丁酸是一种自噬依赖性血管舒张剂。
JCI Insight. 2021 Oct 22;6(20):e149037. doi: 10.1172/jci.insight.149037.
4
β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes.β-羟基丁酸，一种酮体，通过上调心肌细胞中的硫氧还蛋白1增强抗氧化防御。
Antioxidants (Basel). 2021 Jul 20;10(7):1153. doi: 10.3390/antiox10071153.
5
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling.组蛋白去乙酰化酶抑制逆转预先存在的舒张功能障碍并阻止隐匿性细胞外基质重塑。
Circulation. 2021 May 11;143(19):1874-1890. doi: 10.1161/CIRCULATIONAHA.120.046462. Epub 2021 Mar 8.
6
Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure.酮酯治疗改善心力衰竭临床前模型的心脏功能并减少病理性重构。
Circ Heart Fail. 2021 Jan;14(1):e007684. doi: 10.1161/CIRCHEARTFAILURE.120.007684. Epub 2020 Dec 28.
7
Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure.饮食中碳水化合物的限制可抑制心肌肥厚和心力衰竭的发展。
Cardiovasc Res. 2021 Sep 28;117(11):2365-2376. doi: 10.1093/cvr/cvaa298.
8
Ketone metabolism in the failing heart.衰竭心脏中的酮体代谢。
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158813. doi: 10.1016/j.bbalip.2020.158813. Epub 2020 Sep 10.
9
Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress.内源性干细胞和心肌细胞增殖的心脏再生：争议、谬误与进展。
Circulation. 2020 Jul 21;142(3):275-291. doi: 10.1161/CIRCULATIONAHA.119.045566. Epub 2020 Jul 20.
10
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Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22624-22634. doi: 10.1073/pnas.1915905116. Epub 2019 Oct 21.