Ghalib Farhood R, Abd Ali Al-Humairi I
Department of Pathology, College of Medicine, University of Babylon, Babylon, Iraq.
Department of Pathology, Hammurabi College of Medicine, University of Babylon, Babylon, Iraq.
Arch Razi Inst. 2022 Feb 28;77(1):229-234. doi: 10.22092/ARI.2021.356540.1865. eCollection 2022 Feb.
Endometrial hyperplasia is defined as a common clinical disorder caused by the increased levels of estrogens with low levels of progesterone; therefore, this hormonal imbalance leads to an increase in the proliferation rate of the endometrial cells. Endometrial carcinoma is one of the most important malignancies affecting women all over the world "accounting for 37.7% of all other disorders affecting the female reproductive system". The expression of the Ki-67 protein is related to the proliferative behavior of malignant tumor cell populations of their own, allowing it to be used as a marker of tumor aggressiveness. The present study was conducted to examine the expression of the proliferation marker, Ki-67 in various endometrial lesions. Ki-67 expression was evaluated in 60 endometrial samples that resulted as either endometrial curetting or hysterectomy specimens, diagnosed with simple hyperplasia (n=10), complex hyperplasia (n=20), atypical hyperplasia (n=6), and endometrial carcinoma (n=24). In patients with endometrial carcinoma, there was an increased expression of Ki-67, compared to proliferative endometrium and simple hyperplasia (-value=0.0001). There was no such discrepancy between atypical hyperplasia and endometrial carcinoma cases. The expression of Ki-67 showed a positive association with the degree of endometrial cancer (-value=0.0013), however, not with the age of the patients (-value>0.05). There is a wide range of variations in the proliferation rate within the development of different endometrial lesions, including benign and malignant lesions. Our findings may be of value in differential diagnosis and prognosis of endometrial hyperplasia and endometrial carcinoma.
子宫内膜增生被定义为一种常见的临床病症，由雌激素水平升高而孕激素水平降低引起；因此，这种激素失衡导致子宫内膜细胞增殖率增加。子宫内膜癌是影响全球女性的最重要恶性肿瘤之一，“占影响女性生殖系统的所有其他病症的37.7%”。Ki-67蛋白的表达与其自身恶性肿瘤细胞群体的增殖行为相关，使其能够用作肿瘤侵袭性的标志物。本研究旨在检测增殖标志物Ki-67在各种子宫内膜病变中的表达。对60份子宫内膜样本的Ki-67表达进行了评估，这些样本为诊断为单纯增生（n = 10）、复杂性增生（n = 20）、非典型增生（n = 6）和子宫内膜癌（n = 24）的子宫内膜刮除术或子宫切除术标本。与增殖期子宫内膜和单纯增生相比，子宫内膜癌患者中Ki-67表达增加（P值 = 0.0001）。非典型增生和子宫内膜癌病例之间没有这种差异。Ki-67表达与子宫内膜癌的程度呈正相关（P值 = 0.0013），然而与患者年龄无关（P值>0.05）。在不同子宫内膜病变的发展过程中，包括良性和恶性病变，增殖率存在广泛的差异。我们的研究结果可能对子宫内膜增生和子宫内膜癌的鉴别诊断及预后具有价值。
