Chen Pei-Hao, Yang Ya-Yuan, Liao Ying-Yi, Cheng Shih-Jung, Wang Pei-Ning, Cheng Fang-Yu
Department of Neurology, MacKay Memorial Hospital, Taipei 104, Taiwan.
Department of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
Brain Sci. 2022 Jul 26;12(8):990. doi: 10.3390/brainsci12080990.
Mild cognitive impairment (MCI) is considered an intermediate state between normal aging and early dementia. Fear of falling (FOF) could be considered a risk indicator for falls and quality of life in individuals with MCI. Our objective was to explore factors associated with FOF in those with MCI due to Alzheimer's disease (AD-MCI) and mild cognitive impairment in Parkinson's disease (PD-MCI). Seventy-one participants were separated into two groups, AD-MCI ( = 37) and PD-MCI ( = 34), based on the disease diagnosis. FOF was assessed using the Activities-specific Balance Confidence scale. The neuropsychological assessment and gait assessment were also measured. FOF was significantly correlated with global cognitive function, attention and working memory, executive function, Tinetti assessment scale scores, gait speed, and stride length in the AD-MCI group. Moreover, attention and working memory were the most important factors contributing to FOF. In the PD-MCI group, FOF was significantly correlated with gait speed, and time up and go subtask performance. Furthermore, turn-to-walk was the most important factor contributing to FOF. We noted that FOF in different types of MCI was determined by different factors. Therapies that aim to lower FOF in AD-MCI and PD-MCI populations may address attention and working memory and turn-to-walk, respectively.
轻度认知障碍(MCI)被认为是正常衰老与早期痴呆之间的中间状态。害怕跌倒(FOF)可被视为MCI患者跌倒及生活质量的一个风险指标。我们的目的是探讨阿尔茨海默病所致轻度认知障碍(AD-MCI)和帕金森病所致轻度认知障碍(PD-MCI)患者中与FOF相关的因素。根据疾病诊断,71名参与者被分为两组,即AD-MCI组(n = 37)和PD-MCI组(n = 34)。使用特定活动平衡信心量表对FOF进行评估。还进行了神经心理学评估和步态评估。在AD-MCI组中,FOF与整体认知功能、注意力和工作记忆、执行功能、Tinetti评估量表得分、步速和步幅显著相关。此外,注意力和工作记忆是导致FOF的最重要因素。在PD-MCI组中,FOF与步速、起立行走计时测试子任务表现显著相关。此外,转身行走是导致FOF的最重要因素。我们注意到不同类型MCI中的FOF由不同因素决定。旨在降低AD-MCI和PD-MCI人群中FOF的治疗方法可能分别针对注意力和工作记忆以及转身行走。
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