Unit of Medical Oncology and Cancer Prevention, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), 33081 Aviano, Italy.
Unit of Gynecologic Oncology Surgery, IRCCS CRO Aviano, National Cancer Institute, 33081 Aviano, Italy.
Curr Oncol. 2022 Jul 22;29(8):5209-5212. doi: 10.3390/curroncol29080413.
Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for patients with microsatellites instability/mismatch repair deficiency. In this case report, we describe an exceptional and rapid response to dostarlimab in a platinum refractory endometrial cancer patient with high disease burden harboring a mismatch repair deficiency.
直到最近，对于进展为基于铂类的联合治疗的晚期子宫内膜癌，还缺乏有效的治疗方法。在这种情况下，抗 PD-1/PDL-1 单克隆抗体免疫疗法作为一种新的治疗模式，特别是对于微卫星不稳定/错配修复缺陷的患者，正在兴起。在本病例报告中，我们描述了一例高疾病负担的错配修复缺陷铂类耐药子宫内膜癌患者对 dostarlimab 产生的异常快速的反应。
