表观遗传学药物：迈向对多种疾病的理解与治疗
Epidrugs: Toward Understanding and Treating Diverse Diseases.
作者信息
Umehara Takashi
机构信息
Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.
出版信息
Epigenomes. 2022 Jul 12;6(3):18. doi: 10.3390/epigenomes6030018.
Abstract
Epigenomic modifications are unique in the type and amount of chemical modification at each chromosomal location, can vary from cell to cell, and can be externally modulated by small molecules. In recent years, genome-wide epigenomic modifications have been revealed, and rapid progress has been made in the identification of proteins responsible for epigenomic modifications and in the development of compounds that regulate them. This Special Issue on "Epidrugs: Toward Understanding and Treating Diverse Diseases" aims to provide insights into various aspects of the biology and development of epigenome-regulating compounds.
摘要
表观基因组修饰在每个染色体位置的化学修饰类型和数量上是独特的，可因细胞而异，并且可以被小分子进行外部调节。近年来，全基因组表观基因组修饰已被揭示，在负责表观基因组修饰的蛋白质鉴定以及调节它们的化合物开发方面取得了快速进展。本期关于“表观药物：迈向理解和治疗多种疾病”的特刊旨在深入探讨表观基因组调节化合物生物学和开发的各个方面。
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