一种用于转录调控的相分离模型。
A Phase Separation Model for Transcriptional Control.
作者信息
Hnisz Denes, Shrinivas Krishna, Young Richard A, Chakraborty Arup K, Sharp Phillip A
机构信息
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
出版信息
Cell. 2017 Mar 23;169(1):13-23. doi: 10.1016/j.cell.2017.02.007.
Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.
相分离的多分子聚集体提供了一种通用的调控机制，用于在细胞内对生化反应进行区室化。我们提出，相分离模型可以解释转录调控中已确立的和最近描述的特征。这些特征包括超级增强子的形成、超级增强子对扰动的敏感性、增强子的转录爆发模式，以及增强子在多个基因上同时产生激活的能力。该模型提供了一个概念框架，以进一步探索哺乳动物基因调控的原理。
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