结直肠癌合并 2 型糖尿病患者中 、 及 多态性的相关性研究。
Association of , and Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus.
机构信息
Department of Pathology, Emergency Hospital of Constanța, 900591 Constanta, Romania.
CEDMOG Center, Ovidius University of Constanta, 900591 Constanta, Romania.
出版信息
Genes (Basel). 2022 Jul 22;13(8):1297. doi: 10.3390/genes13081297.
BACKGROUND
The aim of the study is to explore the association between the rs7903146, rs6983267 and rs16969681 polymorphisms in patients diagnosed with type 2 diabetes mellitus (T2DM) and colorectal cancer.
METHODS
Sixty individuals were enrolled in this case-control study: thirty with colorectal cancer and type II diabetes mellitus (T2DM) and thirty healthy control individuals. Real-time PCR was used to determine the genotypes of rs7903146, rs 6983267 and rs16969681 in patients with CRC and T2DM and in patients without T2DM and CRC. The Hardy-Weinberg equilibrium was determined in the control group for the genotype distribution of every polymorphism.
RESULTS
People carrying the TT genotype of rs7903146, rs6983267 and rs1696981 had a significant association with T2DM and CRC. Moreover, the people with the TT genotype of rs1696981 had a greater risk for T2DM and CRC (OR = 7, CI 0.397-23.347).
CONCLUSIONS
rs7903146, rs6983267 and rs16969681 could be risk factors for the association of T2DM with CRC.
背景
本研究旨在探讨 2 型糖尿病（T2DM）合并结直肠癌患者 rs7903146、rs6983267 和 rs16969681 多态性与结直肠癌的关系。
方法
本病例对照研究纳入 60 名患者：30 名 T2DM 合并结直肠癌患者，30 名健康对照者。采用实时 PCR 法检测 CRC 和 T2DM 患者及无 T2DM 和 CRC 的患者 rs7903146、rs6983267 和 rs16969681 的基因型。在对照组中， Hardy-Weinberg 平衡检验用于检验每种多态性的基因型分布。
结果
携带 rs7903146、rs6983267 和 rs1696981 TT 基因型的人群与 T2DM 和 CRC 显著相关。此外，rs1696981 TT 基因型的人群发生 T2DM 和 CRC 的风险更大（OR=7，CI 0.397-23.347）。
结论
rs7903146、rs6983267 和 rs16969681 可能是 T2DM 合并结直肠癌的危险因素。
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