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急性卡马西平中毒

Acute Carbamazepine Intoxication.

作者信息

Gallego María Dolores Calabria, García Mónica Alañá

机构信息

IBSAL, Institute for Biomedical Research of Salamanca, 37007 Salamanca, Spain.

Neurology Department, Universitary Hospital of Salamanca, 37007 Salamanca, Spain.

出版信息

Neurol Int. 2022 Jul 22;14(3):614-618. doi: 10.3390/neurolint14030049.

DOI:10.3390/neurolint14030049
PMID:35893284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9331306/
Abstract

Carbamazepine is an anticonvulsant drug with multiple mechanisms of action, which condition the presence of a characteristic clinical picture after the overingestion of the drug. We expose a case report about a patient who, in the context of an attempted suicide, presented acute intoxication by benzodiazepines and carbamazepine, presenting the characteristic clinical picture of fluctuations in the level of consciousness, even presenting gaze deconjugation, almost unreactive coma and generalized hypotonia.

摘要

卡马西平是一种具有多种作用机制的抗惊厥药物,药物过量摄入后会出现典型的临床表现。我们报告一例患者,该患者在自杀未遂时,出现苯二氮䓬类药物和卡马西平急性中毒,表现出意识水平波动的典型临床症状,甚至出现眼球运动分离、几乎无反应性昏迷和全身肌张力减退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/9331306/d1daea0680bd/neurolint-14-00049-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/9331306/be0b1915979f/neurolint-14-00049-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/9331306/d1daea0680bd/neurolint-14-00049-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/9331306/be0b1915979f/neurolint-14-00049-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f01b/9331306/d1daea0680bd/neurolint-14-00049-g002.jpg

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Suicide Ideation among Outpatients with Alcohol Use Disorder.酒精使用障碍门诊患者的自杀意念。
Behav Neurol. 2022 Feb 12;2022:4138629. doi: 10.1155/2022/4138629. eCollection 2022.
2
Combined Hemoperfusion and Continuous Veno-Venous Hemofiltration for Carbamazepine Intoxication.血液灌流联合持续静脉-静脉血液滤过治疗卡马西平中毒
Blood Purif. 2022;51(9):721-725. doi: 10.1159/000520520. Epub 2021 Dec 8.
3
Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia.三叉神经痛的诊断、分类、病理生理学和治疗进展。
急诊科卡马西平中毒的患病率及转归:一项单中心回顾性研究
Indian J Crit Care Med. 2024 Sep;28(9):866-870. doi: 10.5005/jp-journals-10071-24795. Epub 2024 Aug 31.
Lancet Neurol. 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7.
4
The effect of multidrug exposure on neurological manifestations in carbamazepine intoxication: a nested case-control study.多药暴露对卡马西平中毒神经表现的影响:巢式病例对照研究。
BMC Pharmacol Toxicol. 2020 Jun 29;21(1):47. doi: 10.1186/s40360-020-00425-2.
5
Carbamazepine-induced hyperglycemia: A rare case report.卡马西平致高血糖症:一例罕见病例报告。
Indian J Pharmacol. 2019 Sep-Oct;51(5):352-353. doi: 10.4103/ijp.IJP_537_18. Epub 2019 Nov 26.
6
A randomized controlled trial comparing lithium plus valproic acid versus lithium plus carbamazepine in young patients with type 1 bipolar disorder: the LICAVAL study.一项比较锂盐加丙戊酸与锂盐加卡马西平治疗 1 型双相情感障碍年轻患者的随机对照试验:LICAVAL 研究。
Trials. 2019 Oct 26;20(1):608. doi: 10.1186/s13063-019-3655-2.
7
Sodium Channel Blockers in the Treatment of Epilepsy.钠离子通道阻滞剂在癫痫治疗中的应用。
CNS Drugs. 2017 Jul;31(7):527-534. doi: 10.1007/s40263-017-0441-0.
8
Prescribed Benzodiazepines and Suicide Risk: A Review of the Literature.处方苯二氮䓬类药物与自杀风险:文献综述
Prim Care Companion CNS Disord. 2017 Mar 2;19(2). doi: 10.4088/PCC.16r02037.
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Addiction and suicide: A review.成瘾与自杀:综述
Am J Addict. 2015 Mar;24(2):98-104. doi: 10.1111/ajad.12185. Epub 2015 Feb 2.
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Diagnosis of reversible causes of coma.昏迷可逆病因的诊断。
Lancet. 2014 Dec 6;384(9959):2064-76. doi: 10.1016/S0140-6736(13)62184-4. Epub 2014 Apr 21.