Monnier J C, Caron-Grillet C, Vinatier D, Patey-Savatier P, Maunoury-Lefebvre C
Rev Fr Gynecol Obstet. 1987 Mar;82(3):195-8.
46 late interruptions of pregnancy (16 to 33 weeks of amenorrhea) were performed with the use of prostaglandins E1 ovules, of 1 mg, placed in the posterior vaginal cul-de-sac every 12 hours. It concerned 13 deaths in utero or extremely premature rupture of the membranes, 25 fetal indications (9 chromosomal abnormalities and 16 severe malformations), and 8 maternal indications. The efficacy was good either with ovules alone (84.7%) or associated with a balloon probe (5.3%). Expulsion is faster in the case of fetal deaths (average = 8 hours), than in therapeutic interruptions of pregnancy (average = 20 hours). The necessary doses did not exceed 3 mg of PgE1. There were very few side effects, essentially gastro-intestinal in nature and the course was simple. No obstetrical complication was noted. This method is therefore particularly effective with minimal side effects. Easy to use, it must be reserved for very precise indications.
使用1毫克前列腺素E1栓剂，每12小时放置于阴道后穹窿，对46例妊娠中期（闭经16至33周）进行了引产。其中包括13例宫内死亡或胎膜极早破裂、25例胎儿指征（9例染色体异常和16例严重畸形）以及8例母体指征。单独使用栓剂（84.7%）或联合球囊探针（5.3%）的效果均良好。胎儿死亡情况下的排出速度更快（平均 = 8小时），而治疗性引产时排出速度较慢（平均 = 20小时）。所需剂量未超过3毫克前列腺素E1。副作用极少，主要为胃肠道反应，且过程简单。未观察到产科并发症。因此，该方法特别有效且副作用最小。使用方便，但必须严格用于非常明确的指征。
