Mishra Praveen Raman, Bharti Akash, Arora Ridhi, Mir Irfan Ahmad, Punia V P S
Department of Internal Medicine, School of Medical Science & Research, Sharda University, UP, Greater Noida 201306, India.
Pathophysiology. 2022 Jun 21;29(3):326-332. doi: 10.3390/pathophysiology29030024.
Introduction: Hepatitis C virus (HCV) infection is a serious global public health problem. It is estimated that 2% to 3% of the world’s population is infected with the virus. It was found that chronic hepatitis C is an independent predictor of the development of type 2 diabetes mellitus. Infection with HCV or the inflammatory response to HCV infection likely contributes to the development of insulin resistance (IR), which increases the risk of developing type 2 diabetes in the long term. This study aimed to assess the insulin resistance in hepatitis C and its correlation with various metabolic parameters. Materials and Methods: This cross-sectional observational study was conducted at a tertiary care hospital in North India in the Department of Internal Medicine with hepatitis C-positive patients attending an out-patient or in-patient department. We took a total of 100 patients aged > 18 years and divided them into two groups: Group A with hepatitis C (cases) and Group B without hepatitis C (controls). There were a total of 50 hepatitis C patients and 50 patients without hepatitis C. Results: A total of 100 patients were included in the present study after obtaining informed consent. There was a significantly higher level of serum ferritin and insulin in group A patients than group B patients. There was a positive correlation of insulin resistance with the serum insulin, ferritin levels, cholesterol, LDL and triglyceride level and a negative correlation with the serum HDL level. The incidence of insulin resistance was positively correlated with changes in fibrosis in the liver due to the hepatitis C infection. Conclusions: From our study, we found that there is an increased incidence of insulin resistance in the patients with hepatitis-C infection, and insulin resistance is associated with the presence of altered hepatic function test results.
丙型肝炎病毒（HCV）感染是一个严重的全球公共卫生问题。据估计，全球2%至3%的人口感染了该病毒。研究发现，慢性丙型肝炎是2型糖尿病发生的独立预测因素。HCV感染或对HCV感染的炎症反应可能导致胰岛素抵抗（IR）的发生，从长期来看会增加患2型糖尿病的风险。本研究旨在评估丙型肝炎患者的胰岛素抵抗及其与各种代谢参数的相关性。
这项横断面观察性研究在印度北部一家三级护理医院的内科进行，研究对象为门诊或住院部的丙型肝炎阳性患者。我们共纳入了100名年龄大于18岁的患者，并将他们分为两组：A组为丙型肝炎患者（病例组），B组为非丙型肝炎患者（对照组）。共有50名丙型肝炎患者和50名非丙型肝炎患者。
在获得知情同意后，本研究共纳入了100名患者。A组患者的血清铁蛋白和胰岛素水平显著高于B组患者。胰岛素抵抗与血清胰岛素、铁蛋白水平、胆固醇、低密度脂蛋白和甘油三酯水平呈正相关，与血清高密度脂蛋白水平呈负相关。胰岛素抵抗的发生率与丙型肝炎感染导致的肝脏纤维化变化呈正相关。
从我们的研究中发现，丙型肝炎感染患者的胰岛素抵抗发生率增加，且胰岛素抵抗与肝功能检查结果改变有关。
