Henry-Suchet J, Douyeb B
Rev Fr Gynecol Obstet. 1987 Apr;82(4):281-4.
41 cases of acute salpingitis were treated: either with the combination Augmentin + Tetracycline (A + T) including 21 severe cases treated intravenously for 4 days, then per os and 10 moderate cases treated per os from the beginning-or by Augmentin alone (A) per os for 10 other moderate cases. An accurate bacteriological diagnosis was made before treatment and, in case of failure, most often by celioscopy. A Chlamydia serology was performed. Patients were seen again after 8 days (41 cases), one month (39 cases) and several months (32 cases).
A Chlamydia infection was found responsible, by culture or serology, in one out of 2 cases; only one germ was found in 14 cases, 2 germs in 21 cases and none in 7 cases. The association A + T was effective in all moderate cases at 8 and 30 days; in severe forms, there was a failure at 8 days and 4 others at 30 days or 17%. Augmentin alone per os caused 5 failures out of 10 cases at 8 days. No new failure was observed after several months in cases cured at 30 days. The association A + T may be recommended as very effective in moderate forms of acute salpingitis.
对41例急性输卵管炎患者进行了治疗:采用阿莫西林/克拉维酸 + 四环素联合治疗(A + T),其中21例重症患者先静脉注射4天,然后改为口服,另外10例中度患者从一开始就采用口服治疗;或者仅对另外10例中度患者采用口服阿莫西林/克拉维酸(A)治疗。治疗前进行了准确的细菌学诊断,治疗失败时大多通过腹腔镜检查。进行了衣原体血清学检测。分别在8天(41例)、1个月(39例)和数月(32例)后对患者进行复诊。
通过培养或血清学检测发现,2例中有1例衣原体感染;14例仅发现一种病原体,21例发现两种病原体,7例未发现病原体。联合治疗A + T在8天和30天时对所有中度病例均有效;在重症病例中,8天时出现1例治疗失败,30天时出现另外4例治疗失败,即17%。仅口服阿莫西林/克拉维酸在8天时10例中有5例治疗失败。在30天时治愈的病例在数月后未观察到新的治疗失败情况。联合治疗A + T可被推荐为对中度急性输卵管炎非常有效。