生活方式诱导的体重减轻程度决定了 5 年随访期间糖尿病前期和代谢综合征复发的风险。

The Extent of Lifestyle-Induced Weight Loss Determines the Risk of Prediabetes and Metabolic Syndrome Recurrence during a 5-Year Follow-Up.

机构信息

Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany.

Centre for Pediatric Research, Department Woman and Child Health, Hospital for Children and Adolescents, University of Leipzig, 04103 Leipzig, Germany.

出版信息

Nutrients. 2022 Jul 26;14(15):3060. doi: 10.3390/nu14153060.

DOI:10.3390/nu14153060

PMID:35893913

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9331424/

Abstract

It is controversial whether lifestyle-induced weight loss (LIWL) intervention provides long-term benefit. Here, we investigated whether the degree of weight loss (WL) in a controlled LIWL intervention study determined the risk of prediabetes and recurrence of metabolic syndrome (MetS) during a 5-year follow-up. Following LIWL, 58 male participants (age 45−55 years) were divided into four quartiles based on initial WL: Q1 (WL 0−8.1%, n = 15), Q2 (WL 8.1−12.8%, n = 14), Q3 (WL 12.8−16.0%, n = 14), and Q4 (WL 16.0−27.5%, n = 15). We analyzed changes in BMI, HDL cholesterol, triglycerides (TGs), blood pressure, and fasting plasma glucose (FPG) at annual follow-up visits. With a weight gain after LIWL between 1.2 (Q2) and 2.5 kg/year (Q4), the reduction in BMI was maintained for 4 (Q2, p = 0.03) or 5 (Q3, p = 0.03; Q4, p < 0.01) years, respectively, and an increase in FPG levels above baseline values was prevented in Q2−Q4. Accordingly, there was no increase in prediabetes incidence after LIWL in participants in Q2 (up to 2 years), Q3 and Q4 (up to 5 years). A sustained reduction in MetS was maintained in Q4 during the 5-year follow-up. The present data indicate that a greater initial LIWL reduces the risk of prediabetes and recurrence of MetS for up to 5 years.

摘要

生活方式诱导的体重减轻（LIWL）干预是否能提供长期益处存在争议。在这里，我们研究了在一项为期 5 年的随访中，控制的 LIWL 干预研究中体重减轻（WL）的程度是否决定了发生糖尿病前期和代谢综合征（MetS）复发的风险。LIWL 后，根据初始 WL 将 58 名男性参与者（年龄 45-55 岁）分为四组：Q1（WL 0-8.1%，n=15）、Q2（WL 8.1-12.8%，n=14）、Q3（WL 12.8-16.0%，n=14）和 Q4（WL 16.0-27.5%，n=15）。我们分析了 BMI、HDL 胆固醇、甘油三酯（TGs）、血压和空腹血糖（FPG）在每年随访时的变化。在 LIWL 后体重增加 1.2（Q2）至 2.5 公斤/年（Q4）之间，BMI 的减少维持了 4（Q2，p=0.03）或 5 年（Q3，p=0.03；Q4，p<0.01），分别防止了 FPG 水平高于基线值的增加。因此，在 Q2（长达 2 年）、Q3 和 Q4（长达 5 年）中，LIWL 后参与者的糖尿病前期发病率没有增加。在 Q4 中，5 年随访期间持续保持 MetS 的降低。本研究数据表明，更大的初始 LIWL 可降低 5 年内发生糖尿病前期和 MetS 复发的风险。