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神经白塞病较为罕见,但在各种神经学表现,甚至在儿童中,都应考虑到这一疾病。

Neuro-Behçet is a rare disease but should be considered in all kinds of neurological findings, even in childhood.

机构信息

Department of Paediatrics, Department of Paediatric Neurology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Department of Neurology, Bursa Uludag University Medical Faculty, Bursa, Turkey.

出版信息

Clin Exp Rheumatol. 2022 Sep;40(8):1588-1592. doi: 10.55563/clinexprheumatol/lo2dpt. Epub 2022 Jul 22.

Abstract

OBJECTIVES

Behçet's disease (BD) is a vasculitis characterised by eye, musculoskeletal, neurological and gastrointestinal involvement, in addition to recurrent oral ulcers. Neuro-Behçet is the term used to define the nervous system involvement in BD and is very rarely seen in childhood. This study aims to show that neuro-Behçet can manifest a clinical course involving all kinds of neurologic findings in the paediatric population.

METHODS

The Clinic of Paediatric Neurology at Uludag University provides tertiary treatment for children up to eighteen years of age in Bursa, Turkey. Five patients who were clinically diagnosed with Neuro-Behçet in the last 5 years were included in the study.

RESULTS

Seizure, myopathy, transverse myelitis, polyneuropathy, venous thrombosis and facial nerve paralysis were respectively seen in the patients.

CONCLUSIONS

Neuro-Behçet is rare in children, but it is important to know that it can cause various neurological findings, and also systemic findings should be taken into consideration in the diagnosis of neurological diseases. Studies on the neurological involvement of BD in children are inadequate. We believe that paediatric neurologists should be more aware of the neuro-Behçet condition.

摘要

目的

白塞病(BD)是一种血管炎,除了反复发作的口腔溃疡外,还伴有眼部、肌肉骨骼、神经和胃肠道受累。神经白塞病是用于定义 BD 神经系统受累的术语,在儿童中非常罕见。本研究旨在表明神经白塞病在儿科人群中可表现为涉及各种神经系统表现的临床病程。

方法

土耳其布尔萨的乌鲁达大学儿科神经病学诊所为 18 岁以下的儿童提供三级治疗。本研究纳入了过去 5 年内临床诊断为神经白塞病的 5 名患者。

结果

患者分别出现了癫痫发作、肌病、横贯性脊髓炎、多发性神经病、静脉血栓形成和面神经瘫痪。

结论

神经白塞病在儿童中较为罕见,但重要的是要知道它可引起各种神经系统表现,在诊断神经系统疾病时还应考虑到全身表现。关于儿童 BD 神经系统受累的研究不足。我们认为儿科神经病学家应该更加意识到神经白塞病的情况。

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