Department of Pharmaceutical Technology, LJ Institute of Pharmacy, LJ University, Sarkhej, Ahmedabad, Gujarat, 382210, India.
Curr Pharm Biotechnol. 2023;24(8):946-969. doi: 10.2174/1389201023666220727105901.
The nasal route, a subgroup of mucosal delivery systems, constitutes a lucrative and encouraging substitute for administering drugs and vaccines. Over the years, a lot of research has been done in this area, and scientists have successfully explored this pathway using novel formulations to combat several infections. This review article aims to address the pathways of mucosal immunization, the dominance of the nasal route over other mucosal routes for immunization, and the mechanism of generation of immunogenic response via nasal route and nanotechnology-based approaches for intranasal vaccination. The immunotherapeutic and vaccinations for intranasal administration available in the market are also discussed, along with a brief overview of the products in the pipeline. It can also be assumed that such an approach can prove to be favorable in designing vaccinations for the current uncertain times. In spite of some dubious views on this.
鼻腔给药途径是黏膜给药系统的一个亚群，为药物和疫苗的施用提供了一个有吸引力和令人鼓舞的替代方案。多年来，该领域进行了大量研究，科学家们成功地使用新配方探索了这条途径，以对抗多种感染。本文旨在探讨黏膜免疫途径、鼻腔途径相对于其他黏膜途径在免疫接种中的优势，以及通过鼻腔途径和基于纳米技术的方法产生免疫应答的机制，以及鼻腔给药的免疫治疗和疫苗。还讨论了市场上可用于鼻腔给药的免疫治疗和疫苗，并简要介绍了正在研发中的产品。可以假设，这种方法在设计针对当前不确定时期的疫苗时可能是有利的。尽管对此存在一些怀疑的观点。
