Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia.
Am J Trop Med Hyg. 2022 Jun 13;107(2):291-295. doi: 10.4269/ajtmh.22-0050. Print 2022 Aug 17.
Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.
基孔肯雅热病毒（CHIKV）已被确认，但在流行地区很少被认为是中枢神经系统感染的原因。印度尼西亚共有 244 例急性脑膜脑炎患者接受了回顾性检测，以确定是否存在任何与神经表现相关的 CHIKV 感染，特别是在已知存在 CHIKV 流行的省份。使用 CHIKV 特异性实时逆转录聚合酶链反应和 IgM ELISA 以及一组嗜神经病毒对脑脊液（CSF）和血液标本进行了检测。我们报告了四起疑似或确诊的 CHIKV 相关神经疾病病例，包括一例患者的 CSF 中检测到 CHIKV RNA 和另一例患者的急性血清中检测到 CHIKV RNA，以及三例患者的 CSF 中检测到 CHIKV IgM 和第四例患者的血清中检测到 CHIKV IgM。总之，除了更常见的虫媒病毒病，如登革热和日本脑炎病毒外，CHIKV 也应被视为流行地区神经疾病的病因，尤其是在暴发期间。
