Beijing Chest Hospital, Beijing, China.
Thorac Cardiovasc Surg. 2023 Aug;71(5):425-431. doi: 10.1055/s-0042-1749320. Epub 2022 Jul 27.
Thymoma is the most common tumor of the anterior mediastinum. However, the correlation between thymoma stage and pulmonary function was not assessed. Our objective in this study was to describe the pulmonary function in thymoma subjects stratified with different staging systems.
A total of 143 subjects with a diagnosis of thymoma who underwent extended thymectomy for thymoma between January 2001 and December 2019 were reviewed retrospectively. All the subjects experienced pulmonary function tests (PFTs) using Master Screen PFT system and total respiratory resistance measurement.
We evaluated 143 subjects with a diagnosis of thymoma; the significant differences were observed in mean values of vital capacity, inspiratory volume (IC), total lung capacity (TLC), ratio of residual volume to total lung capacity (RV/TLC), forced vital capacity, forced expiratory volume in 1 second, ratio of forced expiratory volume in 1 second to forced vital capacity, peak expiratory flow, peak inspiratory flow, maximum ventilation volume, total airway resistance, and diffusing capacity for carbon monoxide (DLCO) across upper airway obstruction classification. PFTs of subjects with varying Masaoka stages are different. RV and RV/TLC of subjects in stages III and IV were higher than those of normal level, while DLCO of subjects in stage IV was lower than the normal level, and the mean level of IC showed significant difference between stage II and stage III.
The pulmonary function patterns of thymoma subjects significantly correlate with tumor location and size rather than clinical Masaoka stage.
胸腺瘤是前纵隔最常见的肿瘤。然而，胸腺瘤的分期与肺功能之间的相关性尚未得到评估。本研究的目的是描述不同分期系统的胸腺瘤患者的肺功能。
回顾性分析了 2001 年 1 月至 2019 年 12 月期间因胸腺瘤接受扩大胸腺切除术的 143 例诊断为胸腺瘤的患者。所有患者均采用 Master Screen PFT 系统和总呼吸阻力测量法进行肺功能测试（PFT）。
我们评估了 143 例诊断为胸腺瘤的患者；在肺活量、吸气量（IC）、肺总量（TLC）、残气量与肺总量比（RV/TLC）、用力肺活量、1 秒用力呼气量、1 秒用力呼气量与用力肺活量比、呼气峰流量、吸气峰流量、最大通气量、总气道阻力和一氧化碳弥散量（DLCO）等方面，上气道阻塞分类的患者存在显著差异。不同 Masaoka 分期的患者的 PFT 结果不同。III 期和 IV 期患者的 RV 和 RV/TLC 高于正常水平，而 IV 期患者的 DLCO 低于正常水平，II 期和 III 期患者的 IC 平均值也存在显著差异。
胸腺瘤患者的肺功能模式与肿瘤位置和大小显著相关，而与临床 Masaoka 分期无关。
