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瘦素对两种不同光周期条件下急性炎症母羊血液激素谱（皮质醇、胰岛素、甲状腺激素）的影响。

The Effect of Leptin on the Blood Hormonal Profile (Cortisol, Insulin, Thyroid Hormones) of the Ewe in Acute Inflammation in Two Different Photoperiodical Conditions.

机构信息

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 03-105 Jabłonna, Poland.

Department of Animal Nutrition and Biotechnology, and Fisheries, Faculty of Animal Sciences, University of Agriculture in Krakow, 31-120 Krakow, Poland.

出版信息

Int J Mol Sci. 2022 Jul 23;23(15):8109. doi: 10.3390/ijms23158109.

DOI:10.3390/ijms23158109
PMID:35897684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9331064/
Abstract

As a day animal with sensitivity to inflammation similar to that of humans, the sheep may highly outperform the rodent model in inflammation studies. Additionally, seasonality makes sheep an interesting model in endocrinology research. Although there are studies concerning inflammation's influence on leptin secretion and vice versa, a ewe model, with its possible 'long-day leptin resistance', is still not examined enough. The present study aimed to examine whether leptin may modulate an acute inflammation influence on plasma hormones in two photoperiodical conditions. The experiment was conducted on 48 ewes divided into four groups (control, lipopolysaccharide (LPS), leptin, LPS + leptin) during short and long days. Blood sampling started 1 hour before and continued 3 h after LPS/saline administration for further hormonal analysis. The results showed that the photoperiod is one of the main factors influencing the basal concentrations of several hormones with higher values of leptin, insulin and thyroid hormones during long days. Additionally, the acute inflammation effect on cortisol, insulin and thyroid hormones was photoperiod-dependent. The endotoxemia may also exert an influence on leptin concentration regardless of season. The effects of leptin alone on hormone blood concentrations are rather limited; however, leptin can modulate the LPS influence on insulin or thyroxine in a photoperiod-dependent way.

摘要

作为一种与人类炎症敏感性相似的日间动物，绵羊在炎症研究中可能比啮齿动物模型表现得更为出色。此外，季节性使绵羊成为内分泌学研究中一种有趣的模型。尽管有研究涉及炎症对瘦素分泌的影响以及反之亦然，但对于具有“长日瘦素抵抗”可能性的母羊模型，其研究仍不够充分。本研究旨在探讨在两种光照条件下，瘦素是否可以调节急性炎症对血浆激素的影响。该实验在 48 只母羊上进行，分为四组（对照组、脂多糖 (LPS)、瘦素、LPS+瘦素），分别在短日和长日条件下进行。在 LPS/盐水给药前 1 小时开始采血，并持续 3 小时，以进行进一步的激素分析。结果表明，光照是影响几种激素基础浓度的主要因素之一，长日条件下瘦素、胰岛素和甲状腺激素的浓度较高。此外，急性炎症对皮质醇、胰岛素和甲状腺激素的影响依赖于光照周期。内毒素血症也可能对瘦素浓度产生影响，而与季节无关。瘦素本身对激素血液浓度的影响相当有限；然而，瘦素可以调节 LPS 对胰岛素或甲状腺素的影响，这种调节方式依赖于光照周期。

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