Department of Internal Medicine, Franciscan Health Olympia Fields, Olympia Fields, IL 60461, USA.
Department of Gastroenterology, Franciscan Health Olympia Fields, Olympia Fields, IL 60461, USA.
Int J Mol Sci. 2022 Jul 25;23(15):8164. doi: 10.3390/ijms23158164.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. It is well known that repeated inflammatory insults in the liver can cause hepatic cellular injury that lead to cirrhosis and, ultimately, hepatocellular carcinoma. Furthermore, the microbiome has been implicated in multiple inflammatory conditions which predispose patients to malignancy. With this in mind, we explore the inflammatory implications of the microbiome on pathways that lead to HCC. We also focus on how an understanding of these underlying inflammatory principles lead to a more wholistic understanding of this deadly disease, as well as potential therapeutic implications.
肝细胞癌（HCC）是全球癌症相关死亡的第三大主要原因。众所周知，肝脏的反复炎症损伤会导致肝细胞损伤，进而导致肝硬化，最终导致肝细胞癌。此外，微生物组已被牵连到多种炎症状态，使患者易患恶性肿瘤。考虑到这一点，我们探讨了微生物组对导致 HCC 的途径的炎症影响。我们还专注于对这些潜在炎症原理的理解如何导致对这种致命疾病的更全面的理解，以及潜在的治疗意义。
