School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Department of Microbiology, Anatomy, Physiology & Pharmacology, La Trobe University, Bundoora, VIC 3086, Australia.
Molecules. 2022 Jul 25;27(15):4741. doi: 10.3390/molecules27154741.
Citrus bioflavonoids are polyphenolic plant-derived pigments found in high levels in oranges, lemons, grapefruits and other citrus fruits. The three most abundant types of citrus bioflavonoids are hesperidin, naringenin and eriocitrin. Citrus bioflavonoids have long been known to possess powerful free radical-scavenging properties and cardioprotective effects. The study involved the analysis of 10 commercially available citrus bioflavonoid supplements from three different countries: Australia, the United States and Canada. The supplements were tested for their citrus bioflavonoid content which varied from 0.8 to 33.3% /. The daily bioflavonoid dose varied from 19 mg to 560 mg. Hesperidin was the major citrus bioflavonoid in nine out of ten supplements. One supplement was found to contain less than 10% of the quantity of rutin claimed to have been added. The DPP-4 inhibitory potential, compared through an estimation of rutin equivalence, ranged from 1.9 mg to 400 mg per day. This data highlights the variability between the supplements in their potential to inhibit DPP-4 for subsequent health benefits.
柑橘生物类黄酮是在橙子、柠檬、葡萄柚和其他柑橘类水果中含量较高的多酚类植物色素。柑橘生物类黄酮中最丰富的三种类型是橙皮苷、柚皮苷和圣草枸橼苷。长期以来，人们一直知道柑橘生物类黄酮具有强大的自由基清除特性和心脏保护作用。这项研究分析了来自澳大利亚、美国和加拿大三个国家的 10 种市售柑橘生物类黄酮补充剂。这些补充剂的柑橘生物类黄酮含量测试结果从 0.8%到 33.3%不等。每日生物类黄酮剂量从 19 毫克到 560 毫克不等。十种补充剂中有九种的主要柑橘生物类黄酮是橙皮苷。一种补充剂被发现其所含的芦丁量低于声称添加的量的 10%。通过估计芦丁当量，DPP-4 抑制潜力范围从每天 1.9 毫克到 400 毫克。这些数据突出了补充剂之间在抑制 DPP-4 以获得后续健康益处方面的差异。
