Sebastian Juny, Mathew Merrin, Sharsty Veeranna, Ramesh Madhan
Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSS AHER), Mysuru.
Hosp Pharm. 2022 Aug;57(4):564-567. doi: 10.1177/00185787211067379. Epub 2021 Dec 29.
Hypersensitivity or Leukocytoclastic vasculitis (LCV) following the COVID-19 vaccination has been reported rarely all over the world. LCV can be induced by certain factors such as infections, autoimmune disorders, malignancy, or some classes of drugs. A 32-year-old man, who was a known case of seizure disorder from his childhood presented to the department of dermatology with itchy red lesions on extremities and abdomen for the past 1 month. He explains a history of COVID-19 vaccination 1-month back and experienced itching on his lower limbs on the same day at night. A gradual worsening of the condition was observed day by day. He was hospitalized and diagnosed as LCV through clinical and laboratory findings. This case highlights a temporal association with the event of vaccination. The causality assessment showed an indeterminate causal association to LCV with COVID-19 Vaccination.
全球范围内,新冠疫苗接种后出现超敏反应或白细胞破碎性血管炎(LCV)的报道极为罕见。LCV可由某些因素诱发,如感染、自身免疫性疾病、恶性肿瘤或某些种类的药物。一名32岁男性,自幼患有癫痫,过去1个月因四肢和腹部出现瘙痒性红色皮疹就诊于皮肤科。他自述1个月前接种了新冠疫苗,当晚下肢出现瘙痒。此后病情逐渐加重。他住院后,通过临床和实验室检查被诊断为LCV。该病例突出了与疫苗接种事件的时间关联。因果关系评估显示,新冠疫苗接种与LCV之间的因果关联尚不确定。