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新型冠状病毒肺炎疫苗接种后白细胞破碎性血管炎:一例报告

Leukocytoclastic Vasculitis Following COVID-19 Vaccination: A Case Report.

作者信息

Sebastian Juny, Mathew Merrin, Sharsty Veeranna, Ramesh Madhan

机构信息

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSS AHER), Mysuru.

出版信息

Hosp Pharm. 2022 Aug;57(4):564-567. doi: 10.1177/00185787211067379. Epub 2021 Dec 29.

Abstract

Hypersensitivity or Leukocytoclastic vasculitis (LCV) following the COVID-19 vaccination has been reported rarely all over the world. LCV can be induced by certain factors such as infections, autoimmune disorders, malignancy, or some classes of drugs. A 32-year-old man, who was a known case of seizure disorder from his childhood presented to the department of dermatology with itchy red lesions on extremities and abdomen for the past 1 month. He explains a history of COVID-19 vaccination 1-month back and experienced itching on his lower limbs on the same day at night. A gradual worsening of the condition was observed day by day. He was hospitalized and diagnosed as LCV through clinical and laboratory findings. This case highlights a temporal association with the event of vaccination. The causality assessment showed an indeterminate causal association to LCV with COVID-19 Vaccination.

摘要

全球范围内,新冠疫苗接种后出现超敏反应或白细胞破碎性血管炎(LCV)的报道极为罕见。LCV可由某些因素诱发,如感染、自身免疫性疾病、恶性肿瘤或某些种类的药物。一名32岁男性,自幼患有癫痫,过去1个月因四肢和腹部出现瘙痒性红色皮疹就诊于皮肤科。他自述1个月前接种了新冠疫苗,当晚下肢出现瘙痒。此后病情逐渐加重。他住院后,通过临床和实验室检查被诊断为LCV。该病例突出了与疫苗接种事件的时间关联。因果关系评估显示,新冠疫苗接种与LCV之间的因果关联尚不确定。

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Diagnosis and management of leukocytoclastic vasculitis.白细胞碎裂性血管炎的诊断与治疗。
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