Patnaik Nabnita, Mishra Kumar Guru, Pradhan Nihar Ranjan
Obstetrics and Gynecology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, IND.
Community Medicine and Family Medicine, All India Institute of Medical Sciences, Bibinagar, Hyderabad, IND.
Cureus. 2022 Jun 23;14(6):e26236. doi: 10.7759/cureus.26236. eCollection 2022 Jun.
Low testosterone is usually associated with erectile dysfunction (ED). SA3X () has proven to be effective in alleviating symptoms of ED, which could be due to an alteration in serum testosterone levels. This study was carried out to evaluate the change in testosterone levels in participants with ED supplemented with SA3X for three months.
A group of 326 sexually active men aged 25-60 years was investigated from November 2021 to May 2022 in Hyderabad. The participants were subjected to supplementation with SA3X capsules for three months, and a follow-up was done at the end of six months with serum testosterone assessment in each visit. The change in testosterone level was assessed using a mixed model repeated measures analysis.
A significant increase was observed in the mean serum testosterone levels by the end of the second month (323.91 ± 13.76 ng/dL vs. 309.84 ± 14.11 ng/dL; p=0.03) and third month (332.27 ± 12.85 ng/dL vs. 309.84 ± 14.11 ng/dL; p<0.01) of SA3X therapy. The adjusted mean change in testosterone levels was found to be 22.43 ng/dL at the end of the three-month therapy. It was also observed that the change in testosterone levels was significantly lower in participants having diabetes mellitus, hypercholesterolemia, and a history of substance abuse. However, participants on phosphodiesterase-5 inhibitors had an increased change in testosterone levels.
Supplementation with SA3X capsules for three months increases the serum testosterone levels. However, causality cannot be ascertained owing to the longitudinal nature of the study, and further controlled trials are required for the same.
低睾酮通常与勃起功能障碍（ED）相关。SA3X（）已被证明可有效缓解ED症状，这可能是由于血清睾酮水平的改变。本研究旨在评估补充SA3X三个月的ED参与者的睾酮水平变化。
2021年11月至2022年5月在海得拉巴对一组326名年龄在25至60岁之间有性活动的男性进行了调查。参与者接受SA3X胶囊补充三个月，并在六个月结束时进行随访，每次随访均评估血清睾酮。使用混合模型重复测量分析评估睾酮水平的变化。
在SA3X治疗的第二个月末（323.91±13.76 ng/dL对309.84±14.11 ng/dL；p = 0.03）和第三个月末（332.27±12.85 ng/dL对309.84±14.11 ng/dL；p<0.01）观察到平均血清睾酮水平显著升高。在三个月治疗结束时，发现睾酮水平的调整后平均变化为22.43 ng/dL。还观察到，患有糖尿病、高胆固醇血症和有药物滥用史的参与者的睾酮水平变化显著较低。然而，使用磷酸二酯酶-5抑制剂的参与者的睾酮水平变化有所增加。
补充SA3X胶囊三个月可提高血清睾酮水平。然而，由于研究的纵向性质，无法确定因果关系，对此需要进一步的对照试验。
