Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC.

We investigated the genetic predisposition for the pathogenesis of Stevens-Johnson syndrome/epidermal necrolysis with severe ocular complications (SJS/TEN with SOC). Cold medicines (CMs) including multi-ingredient cold-medications and non-steroidal anti-inflammatory drugs (NSAIDs) were implicated in the development of SJS/TEN with SOC. Studies on the association between HLA genotypes and CM-related SJS/TEN with SOC (CM-SJS/TEN with SOC) revealed an association with in the Japanese; it may be a marker in Koreans. was associated with the Japanese, Thais, and Indians; in Brazilians of European ancestry, it may be a positive marker. is a susceptibility gene; and polymorphisms exerted additive effects in Japanese and Korean patients. A genome-wide association study showed that was associated with the Japanese. A meta-analysis including Japanese, Koreans, Indians, and Brazilians also revealed an association between CM-SJS/TEN with SOC and The upregulation of hsa-miR-628-3p in the plasma of SJS/TEN with SOC patients may suppress the expression of and innate immune-related genes. Not only CMs but also the interaction of , , , and and maybe some microbial infections are necessary for the onset of SJS/TEN with SOC.