用于递送生长因子以调节伤口修复的生物材料的研究进展
[Research advances on biomaterials for the delivery of growth factors to regulate wound repair].
作者信息
Weng T T, Cai C H, Han C M, Wang X G
机构信息
The Second Clinical College, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Department of Burn and Wound Repair, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Jul 20;38(7):691-696. doi: 10.3760/cma.j.cn501225-20220430-00166.
Abstract
Wound repair is a highly coordinated and mutually regulated complex process involving various kinds of cells, extracellular matrices and cytokines. A variety of growth factors play an important regulatory role in wound healing, and it is critical to achieve effective delivery and sustained function of growth factors. In recent years, the application of biomaterials in tissue engineering has shown great potential, and the effective delivery of growth factors by biomaterials has attracted increasing attention. Based on this, this paper introduces the mechanism of related growth factors in the process of wound healing, focusing on the recent progress of biomaterial delivery of growth factors to accelerate wound healing, in order to provide new enlightenment for clinical wound treatment.
摘要
伤口修复是一个高度协调且相互调节的复杂过程，涉及多种细胞、细胞外基质和细胞因子。多种生长因子在伤口愈合中发挥着重要的调节作用，实现生长因子的有效递送和持续功能至关重要。近年来，生物材料在组织工程中的应用显示出巨大潜力，生物材料对生长因子的有效递送已引起越来越多的关注。基于此，本文介绍相关生长因子在伤口愈合过程中的作用机制，重点阐述生物材料递送生长因子以加速伤口愈合的研究进展，以期为临床伤口治疗提供新的启示。
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