雅加达与年龄相关的新生血管性黄斑变性患者的干扰素 -γ循环水平。

Circulating levels of Interferon-Gamma in patients with neovascular age-related macular degeneration in Yogyakarta.

机构信息

Universitas Gadjah Mada, Public Health and Nursing, Faculty of Medicine, Department of Ophthalmology, Sekip Utara, Yogyakarta, Indonesia.

Nara Institute of Science and Technology, Laboratory of Gene Function in Animals, Takayama, Ikoma, Nara, Japan.

出版信息

Med J Malaysia. 2022 Jul;77(Suppl 1):62-65.

PMID:35899892

Abstract

INTRODUCTION

Neovascular age-related macular degeneration (nAMD) is a major factor contributing to blindness and impaired visual acuity in elderly people. The pathophysiology of nAMD involves excessive inflammation events in the macula. Thus, it is crucial to study the dynamics of an important pro-inflammatory cytokine, interferon-gamma (IFN-γ).

MATERIALS AND METHODS

This research is aimed to investigate plasma IFN-γ profiles of patients with nAMD. In this crosssectional study, blood plasma samples of 16 patients with AMD and 23 age-matched controls were collected. Samples were examined for two inflammatory cytokines (IFN-γ) using a commercially available enzyme-linked immunosorbent assay.Acquired data were log transformed to normalize any outliers before conducting student'st-test using the SPSS software.

RESULTS

IFN-γ levels were higher in the control group, without statistically significant difference between the two groups.

CONCLUSION

IFN-γ levels were not significantly different between patients with AMD and controls.

摘要

简介

新生血管性年龄相关性黄斑变性（nAMD）是导致老年人失明和视力下降的主要因素。nAMD 的病理生理学涉及黄斑区过度的炎症事件。因此，研究重要的促炎细胞因子干扰素-γ（IFN-γ）的动力学至关重要。

材料和方法

本研究旨在研究 nAMD 患者的血浆 IFN-γ谱。在这项横断面研究中，采集了 16 名 AMD 患者和 23 名年龄匹配的对照者的血浆样本。使用商业上可用的酶联免疫吸附试验检测两种炎症细胞因子（IFN-γ）。使用 SPSS 软件对获得的数据进行对数转换，以在进行学生 t 检验之前对任何异常值进行归一化。