Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Pathol Microbiol. 2022 Jul-Sep;65(3):551-557. doi: 10.4103/ijpm.ijpm_824_21.
Gastric neuroendocrine tumors (G-NETs) are classified into well-differentiated NETs with three grades and poorly differentiated neuroendocrine carcinomas based on morphology and the Ki-67 index. Besides, G-NETs are broadly classified into four types based on clinical and pathophysiological features.
To study clinical and pathological features of different types and grades of G-NET.
All G-NETs, diagnosed from January 2011 to December 2020, were included. Clinical presentation, peritumoral findings, lymph node status, and liver involvement were obtained and correlated with different grades and types of G-NETs.
NET was diagnosed in 88 cases. Tumors were graded as I, II, III, and carcinoma in 58, 14, 12, and 4 cases, respectively. Type I NET (49.2%) in the background of chronic atrophic gastritis was the most common type followed by type III (33.3%). Type I tumors were predominantly graded I (91.1%) and limited to the mucosa and submucosa. MEN-1-associated G-NET (type II) was seen in eight cases. All except one type II tumor was associated with ZES syndrome. Remarkably, peritumoral mucosa showed atrophy and intestinal metaplasia in 52.1% and 24.6% cases, respectively. Two cases were associated with adenocarcinoma. Lymph node metastasis was seen in all carcinoma and grade III cases. All carcinoma cases and 58.3% of grade III tumors showed liver metastasis.
Biological behavior of G-NET varies with different types and grades of tumor. Typing and grading of G-NET should be done whenever possible to predict the aggressiveness of the tumor.
胃神经内分泌肿瘤（G-NET）基于形态学和 Ki-67 指数可分为分化良好的 NET 三级和分化差的神经内分泌癌。此外，G-NET 还可根据临床和病理生理特征广泛分为四型。
研究不同类型和分级的 G-NET 的临床和病理特征。
纳入 2011 年 1 月至 2020 年 12 月期间诊断的所有 G-NET。获取临床表现、肿瘤周围表现、淋巴结状态和肝转移情况，并与不同分级和类型的 G-NET 相关联。
诊断为 NET 88 例。肿瘤分级为 I 级、II 级、III 级和癌者分别为 58、14、12 和 4 例。以慢性萎缩性胃炎为背景的 I 型 NET（49.2%）是最常见的类型，其次是 III 型（33.3%）。I 型肿瘤主要分级为 I 级（91.1%）且局限于黏膜和黏膜下层。MEN-1 相关的 G-NET（II 型）见 8 例。除 1 例外，所有 II 型肿瘤均与 ZES 综合征相关。值得注意的是，52.1%和 24.6%的病例分别有肿瘤周围黏膜萎缩和肠上皮化生。2 例与腺癌相关。所有癌和 III 级病例均有淋巴结转移。所有癌病例和 58.3%的 III 级肿瘤均有肝转移。
G-NET 的生物学行为因肿瘤的不同类型和分级而异。应尽可能对 G-NET 进行分型和分级，以预测肿瘤的侵袭性。
