Department of Pulmonary Medicine, AIIMS Bhopal, Bhopal, Madhya Pradesh, India.
Department of CTVS, AIIMS Bhopal, Bhopal, Madhya Pradesh, India.
Indian J Pathol Microbiol. 2022 Jul-Sep;65(3):653-656. doi: 10.4103/IJPM.IJPM_1158_20.
We describe three postmortem open lung-biopsy findings among patients with COVID-19 pneumonia who were on anticoagulant therapy. The spectrum of histopathological findings included lung inflammation in the form of diffuse alveolar damage (DAD) in exudative and organizing phases, with or without pulmonary artery thrombosis in different stages of evolution. This spectrum of inflammation and thrombosis may be indicative of a natural history of severe COVID-19 pneumonia or demonstrative of variation in therapeutics.
我们描述了 COVID-19 肺炎患者在抗凝治疗下进行的三次死后开胸肺活检的发现。组织病理学发现的范围包括渗出性和机化性弥漫性肺泡损伤（DAD）形式的肺部炎症，伴有或不伴有不同演变阶段的肺动脉血栓形成。这种炎症和血栓形成的范围可能提示严重 COVID-19 肺炎的自然病程，或者表明治疗方法的差异。
