Department of Pathology, Post Graduate Institute of Medical Education and Research (PGIMER), Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS), Ram Manohar Lohia Hospital (RML), New Delhi, India.
Deparment of Pathology and Laboratory Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
Indian J Pathol Microbiol. 2022 Jul-Sep;65(3):679-682. doi: 10.4103/ijpm.ijpm_576_21.
Small intestinal medullary carcinoma (MC) is a newly recognized subclass of small intestinal carcinomas and is an exceptional entity for this site. A search of the literature for similar cases arising in the small intestine revealed only six previously reported cases. Here we present a case of MC arising in the jejunum of a 65-year-old male. The patient presented to the emergency with features of perforation peritonitis with liver metastasis and no known predisposing factors like inflammatory bowel disease and celiac disease. Studies conducted on this tumor's colonic counterpart have shown microsatellite instability (MSI) and B-type Raf kinase (BRAF) mutations; however, few exceptions are known. Also, this subtype of carcinoma is known to have a better prognosis than its other histological subtypes.
小肠髓样癌（MC）是一种新确认的小肠癌亚类，是该部位的一种特殊实体。对文献中类似发生于小肠的病例进行检索，仅发现之前有 6 例报道。在此，我们报告 1 例发生于 65 岁男性空肠的 MC。该患者因穿孔性腹膜炎伴肝转移就诊，无已知的易患因素，如炎症性肠病和乳糜泻。对该肿瘤结肠对应物的研究表明存在微卫星不稳定性（MSI）和 B 型 Raf 激酶（BRAF）突变；然而，已知存在一些例外情况。此外，与其他组织学亚型相比，这种类型的癌预后更好。
