Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India.
Department of Otorhinolaryngology and Head and Neck Surgery, Kasturba Medical College, Mangalore, Karnataka, India.
J Cancer Res Ther. 2022 Apr-Jun;18(3):804-806. doi: 10.4103/jcrt.JCRT_617_20.
Spindle cell carcinoma of the head and neck is a rare biphasic neoplasm. The presentation mimics other head-and-neck malignancies and hence the diagnosis hinges upon histopathological confirmation along with positive immunohistochemistry (IHC) markers denoting the presence of both epithelial and mesenchymal components. At present, there are no standard management criteria for these tumors with the options varying from surgery alone to surgery combined with adjuvant radiotherapy. We discuss here the case of a patient presenting with an oropharyngeal mass that had benign clinical features and the final diagnosis of spindle cell carcinoma could only be established after histopathology with IHC typing.
头颈部梭形细胞癌是一种罕见的双相性肿瘤。其表现类似于其他头颈部恶性肿瘤,因此诊断取决于组织病理学确认,以及免疫组织化学(IHC)标志物的阳性结果,这些标志物表示上皮和间充质成分均存在。目前,这些肿瘤没有标准的管理标准,治疗方案从单纯手术到手术联合辅助放疗不等。我们在此讨论了一位患者的病例,该患者表现为口咽肿块,临床特征为良性,只有经过组织病理学和 IHC 分型才能最终诊断为梭形细胞癌。