Adauto Luizaga Jhoanna, Costa Almar Florencia, Zwirner Agustina, Fernández Polivanoff M Lucía, Suárez Ramiro F, Rossi Santiago, Pascual Carolina
Clínica Pediátrica, Hospital de Niños Dr. Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina.
Arch Argent Pediatr. 2022 Aug;120(4):e183-e186. doi: 10.5546/aap.2022.e183. Epub 2022 Jun 7.
Encephalitis are frequent clinical pictures in pediatric age. They can be divided into those caused by infection of the central nervous system and those of immune-mediated etiology (some of which may be para- or post-infectious). In March 2020, the WHO declared a SARS-CoV-2 pandemic. Pediatric reports of disease caused by this agent describe a wide range of clinical manifestations: respiratory and gastrointestinal compromise, neurological symptoms, among others; and a multisystemic inflammatory syndrome in children associated with COVID-19 (MIS-C). We describe the case of a 2-year-old boy with a diagnosis of anti-NMDAR antibody encephalitis, in whom a recent SARS-CoV-2 infection was serologically proven. The presence of positive serological markers for SARS-CoV-2 in a patient who presented encephalitis due to anti-NMDAR antibodies could be interpreted as a temporal association; establishing the possibility that the virus has acted as a trigger for an autoimmune disease.
脑炎是儿科常见的临床病症。它们可分为由中枢神经系统感染引起的和免疫介导病因（其中一些可能是感染前或感染后）引起的。2020年3月，世界卫生组织宣布新型冠状病毒肺炎大流行。关于这种病原体所致疾病的儿科报告描述了广泛的临床表现：呼吸和胃肠道功能损害、神经症状等；以及与新型冠状病毒肺炎相关的儿童多系统炎症综合征（MIS-C）。我们描述了一名2岁男孩的病例，该男孩被诊断为抗N-甲基-D-天冬氨酸受体（NMDAR）抗体脑炎，血清学证实近期感染了新型冠状病毒。在一名因抗NMDAR抗体而出现脑炎的患者中，新型冠状病毒血清学标志物呈阳性，这可能被解释为一种时间上的关联；这表明该病毒有可能引发了自身免疫性疾病。
