评估药物对人体冠状动脉血流影响的方法。
Methods for the assessment of the effects of drugs on coronary blood flow in man.
作者信息
Swanton R H, Coltart D J
出版信息
Br J Clin Pharmacol. 1978 Oct;6(4):285-95. doi: 10.1111/j.1365-2125.1978.tb00854.x.
Abstract
The methods currently available for measurement of coronary blood flow in man are reviewed and their advantages and limitations discussed. Most of the techniques are invasive and involve cardiac catheterization. The least invasive isotope techniques are either not quantitative or involve expensive equipment not available in many centres. Two of the most suitable methods for assessing the effects of drugs on coronary flow are coronary sinus thermodilution and isotope washout curves using 133xenon or [125I]-iodo-antipyrine. The ideal technique for measuring coronary blood flow has yet to be developed.
摘要
本文回顾了目前可用于测量人体冠状动脉血流的方法，并讨论了它们的优缺点。大多数技术都是侵入性的，需要进行心导管插入术。侵入性最小的同位素技术要么无法定量，要么需要昂贵的设备，许多中心都没有。评估药物对冠状动脉血流影响的两种最合适方法是冠状窦热稀释法和使用133氙或[125I] - 碘安替比林的同位素洗脱曲线法。测量冠状动脉血流的理想技术尚未开发出来。
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