Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Ocul Immunol Inflamm. 2022 Apr 3;30(3):690-696. doi: 10.1080/09273948.2022.2075399.
The current gold standard to grade vitreous inflammation is the Nussenblatt scale based in clinical examination, published in 1985. Nowadays a big effort is undergoing to come out with more objective and reliable methods based in optical coherence (OCT) imaging analysis.
A systematic review was done to identify the articles that quantify or assess qualitatively vitreous inflammation with OCT.
Twelve papers were included. Only one paper analyzed qualitatively the anatomy of the vitreous body and its potential influence in cystoid macular edema, while the rest assessed vitreous inflammation quantitatively using the relative reflectivity of the vitreous body with different retinal structures or quantifying the hyperreflective dots in the vitreous.
The new development of OCT-based scales for measuring vitreous inflammation could replace the current clinical grading scales as an end point for future clinical trials.
目前用于玻璃体炎症分级的金标准是基于临床检查的 Nussenblatt 量表，该量表于 1985 年发表。如今，人们正在努力开发基于光相干（OCT）成像分析的更客观、更可靠的方法。
进行了系统评价，以确定定量或定性评估 OCT 玻璃体炎症的文章。
共纳入 12 篇论文。只有一篇论文定性分析了玻璃体的解剖结构及其对囊样黄斑水肿的潜在影响，而其余论文则使用玻璃体与不同视网膜结构的相对反射率或量化玻璃体中的高反射点来定量评估玻璃体炎症。
基于 OCT 的玻璃体炎症测量量表的新发展可能会取代当前的临床分级量表，成为未来临床试验的终点。
