胆碱酯酶复活剂和阿托品对水牛体内杀螟硫磷诱导的体温过低的影响。

Effects of cholinesterase reactivators and atropine on fenitrothion-induced hypothermia in Bubalus bubalis.

作者信息

Malik J K, Srivastava A K

出版信息

Toxicol Lett. 1987 May;36(3):289-95. doi: 10.1016/0378-4274(87)90198-6.

Abstract

Oral administration of fenitrothion (435 mg/kg) produced a pronounced fall in rectal temperature and erythrocyte AChE activity in buffalo calves. Treatment with DAM alone or in conjunction with atropine at the time of severe toxicity (within 1 h) significantly (P less than 0.01) reversed fenitrothion-induced hypothermia and AChE inhibition. The temperature decrease and AChE inhibition were not significantly (P greater than 0.05) altered by either 2-PAM or atropine. It is concluded that DAM may be more effective than either 2-PAM or atropine in reversing hypothermic effect of OP insecticides.

摘要

给水牛犊口服杀螟硫磷（435毫克/千克）会使其直肠温度显著下降，红细胞乙酰胆碱酯酶（AChE）活性降低。在出现严重毒性时（1小时内）单独使用解磷定（DAM）或与阿托品联合使用，可显著（P小于0.01）逆转杀螟硫磷引起的体温过低和AChE抑制。2-吡啶甲醛肟甲基碘（2-PAM）或阿托品对温度降低和AChE抑制均无显著（P大于0.05）影响。得出的结论是，在逆转有机磷杀虫剂的体温过低效应方面，解磷定可能比2-吡啶甲醛肟甲基碘或阿托品更有效。