Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids.
作者信息
Campagna F, Altomare C, Carotti A, Casini G, Ferappi M
出版信息
Steroids. 1986 Apr-May;47(4-5):307-20. doi: 10.1016/0039-128x(86)90100-5.
PMID:3590241
Abstract
The synthesis of unsaturated derivatives of 8-aza-11-oxa-17-oxo-gonane and D-homo-gonane carrying one or two functional substituents at C-12 is reported. The key step for the construction of the heterosteroid skeleton was the cyclocondensation reaction of aldol adducts 1, derived from 1,3-cycloalkanediones and diethyl 2-oxo-malonate, with tosyl chloride and isoquinoline.
摘要
相似文献
1
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids.
Steroids. 1986 Apr-May;47(4-5):307-20. doi: 10.1016/0039-128x(86)90100-5.
2
Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding.
J Med Chem. 1986 Nov;29(11):2298-315. doi: 10.1021/jm00161a028.
3
Azasteroids as inhibitors of rat prostatic 5 alpha-reductase.
J Med Chem. 1984 Dec;27(12):1690-701. doi: 10.1021/jm00378a028.
4
[Synthetic studies of salamander alkaloids, an animal venom].
Yakugaku Zasshi. 1980 Mar;100(3):227-40. doi: 10.1248/yakushi1947.100.3_227.
5
A novel synthesis of 8-aza steroids.
J Org Chem. 1975 Jan 10;40(1):50-4. doi: 10.1021/jo00889a011.
6
Heterocyclic steroids. Part II. Synthesis of (+/-)-8-hydroxy-3-methoxy-11-aza-18-norestra-1,3,5(10),9(11)-tetraen-17-one and related compounds.
J Chem Soc Perkin 1. 1976(17):1889-93.
7
8
Photocyclisation of enamides. Part XI. Syntheses of benzo[i]phenanthridines related to Aza-steroids.
J Chem Soc Perkin 1. 1976(17):1868-72. doi: 10.1039/p19760001868.
9
Apparent bioisosteric replacement of--S--by NCN: synthesis of N--cyano-2-aza-A-nor-5alpha-androstan-17beta-ol acetate, an aza steroid androgen.
J Med Chem. 1979 Jan;22(1):119-20. doi: 10.1021/jm00187a028.
10
Syntheses and ultraviolet absorption of aza-steroids.氮杂甾体的合成与紫外吸收
Steroids. 1976 Feb;27(2):225-34. doi: 10.1016/0039-128x(76)90099-4.
Zotero 插件