Department of Cardiology Clinic, Pursaklar State Hospital, 39 Cagatay Street, Pursaklar, Mimar Sinan District, 06145, Ankara, Turkey.
Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
BMC Cardiovasc Disord. 2022 Jul 28;22(1):337. doi: 10.1186/s12872-022-02788-2.
Peripheral arterial disease (PAD) causes significant morbidity today. Atherosclerosis is evident in the pathophysiological process in most patients, so PAD has similar risk factors as coronary artery disease. Platelet-Hemoglobin ratio (PHR) has been proven to predict mortality in atherosclerotic heart disease. We aimed to determine the relationship between PHR and below-knee amputation.
The study is a single-center retrospective study. Platelet count/hemoglobin amount formula was used for PHR. Only PAD patients with below-knee critical extremity ischemia and unsuitable for revascularization were included in the study.
235 patients were included in the study retrospectively. The mean age was 65.7 ± 9.9 years and 175(74.5%) of them were male. In the amputated group, white blood cell, neutrophil, platelet, creatinine, glucose, and PHR were higher (p = .031, p = .045, p = .011, p = .048 p = .018, p = .004, respectively). Only hemoglobin values were lower (p = .003). Multivariable regression analysis showed; age, albumin and PHR were determined as independent risk factors for amputation (Age; OR (95%CI): (1.094(1.040-1.152), p = .001) (Albumin; OR (95% CI): 1.950(1.623-1.799), p = .001) (PHR; OR (95% CI): 1.872(1.246-2.812), p = .003). Receiver operating characteristics analysis performed to determine the optimal cut-off value of PHR for amputation, the optimal value was found 2.08 (65.8% sensitivity, 67.5% specificity, p < .001).
PHR was a good predictor for BKA. Using the PHR, it may be possible to identify high-risk patients for amputation.
外周动脉疾病（PAD）目前导致了大量的发病率。在大多数患者中，动脉粥样硬化在病理生理过程中很明显，因此 PAD 与冠状动脉疾病有相似的危险因素。血小板-血红蛋白比值（PHR）已被证明可预测动脉粥样硬化性心脏病的死亡率。我们旨在确定 PHR 与膝下截肢之间的关系。
本研究为单中心回顾性研究。使用血小板计数/血红蛋白量公式计算 PHR。本研究仅纳入有膝下严重肢体缺血且不适合血运重建的 PAD 患者。
回顾性纳入 235 例患者。平均年龄为 65.7±9.9 岁，175 例（74.5%）为男性。在截肢组中，白细胞、中性粒细胞、血小板、肌酐、葡萄糖和 PHR 较高（p=0.031，p=0.045，p=0.011，p=0.048，p=0.018，p=0.004）。只有血红蛋白值较低（p=0.003）。多变量回归分析显示；年龄、白蛋白和 PHR 是截肢的独立危险因素（年龄；OR（95%CI）：（1.094（1.040-1.152），p=0.001）（白蛋白；OR（95%CI）：1.950（1.623-1.799），p=0.001）（PHR；OR（95%CI）：1.872（1.246-2.812），p=0.003）。为确定 PHR 对截肢的最佳截断值进行了受试者工作特征分析，发现最佳值为 2.08（65.8%敏感性，67.5%特异性，p<0.001）。
PHR 是 BKA 的良好预测指标。使用 PHR 可能可以识别出高截肢风险的患者。
