白细胞介素、IL-37 和 IL-38 在幼年特发性关节炎患者中的生物标志物意义。

Biomarker significance of interleukins, IL-37 and IL-38 in patients with juvenile idiopathic arthritis.

机构信息

University of Baghdad, College of Medicine, Department of Microbiology & Immunology, Baghdad, Iraq.

出版信息

Med J Malaysia. 2022 Jul;77(4):415-419.

Abstract

INTRODUCTION

Juvenile idiopathic arthritis (JIA) is the most common rheumatic condition that develops during child age and adolescence. Unbalanced production of proinflammatory cytokines is suggested to participate in the etio-pathogenesis of JIA, so the objective of this study is to evaluate the role of interleukins (IL), IL-37 and IL-38, in patients with JIA.

MATERIALS AND METHODS

Sixty patients with JIA (19 males, 41 females) and 90 healthy controls (35 males, 55 females) were included in this study. Participants were assessed using the juvenile arthritis disease activity score-27 and underwent laboratory tests, including measurements for C-reactive protein, rheumatoid factor, and IL-37 and IL-38.

RESULTS

Mean ages of JIA patients and controls were 10.37±4.21 years and 11.13±3.84 years, respectively. Compared to controls, serum IL-37 levels were increased in patients with JIA (117.98±209.282ng/ml vs. 37.87±24.496ng/ml; p<0.01), whereas serum IL-38 titres were diminished in individuals with JIA (106.2±95.781ng/ml vs. 182.24±108.428 ng/ml; p<0.01).

CONCLUSION

This study provides a further layer of evidence for the role played by IL-37 in JIA and creates new questions about the potential role of IL-38 in this condition.

摘要

简介

幼年特发性关节炎（JIA）是儿童和青少年时期最常见的风湿性疾病。促炎细胞因子的失衡产生被认为参与了 JIA 的病因发病机制，因此本研究旨在评估白细胞介素（IL）、IL-37 和 IL-38 在 JIA 患者中的作用。

材料和方法

本研究纳入了 60 名 JIA 患者（19 名男性，41 名女性）和 90 名健康对照者（35 名男性，55 名女性）。使用幼年特发性关节炎疾病活动评分-27 对参与者进行评估，并进行实验室检查，包括 C 反应蛋白、类风湿因子以及 IL-37 和 IL-38 的测量。

结果

JIA 患者和对照组的平均年龄分别为 10.37±4.21 岁和 11.13±3.84 岁。与对照组相比，JIA 患者的血清 IL-37 水平升高（117.98±209.282ng/ml 比 37.87±24.496ng/ml；p<0.01），而血清 IL-38 浓度降低（106.2±95.781ng/ml 比 182.24±108.428ng/ml；p<0.01）。