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病例报告:奥马珠单抗成功治疗一名患有多种合并症的老年患者的顽固性大疱性类天疱疮。

Case Report: Omalizumab Successfully Treated Recalcitrant Bullous Pemphigoid in an Elderly Patient with Multiple Comorbidities.

作者信息

Liu Jue, Xiang Tingkai, Wang Wei, Bu Zhangyu

机构信息

Department of Dermatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

The Fourth School of Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2022 Jul 21;15:1391-1396. doi: 10.2147/CCID.S373682. eCollection 2022.

DOI:10.2147/CCID.S373682
PMID:35903519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9314756/
Abstract

Bullous pemphigoid (BP) is an autoimmune blistering disease mainly affecting elderly individuals. Comorbidities are common in patients with BP and have been found to complicate the management and prognosis. We describe a patient with multiple comorbidities who was successfully treated with omalizumab and suggest omalizumab as a good alternative therapy for BP to prevent treatment-related complications in elderly patients with a poor general condition.

摘要

大疱性类天疱疮(BP)是一种主要影响老年人的自身免疫性水疱病。合并症在BP患者中很常见,并且已发现会使治疗和预后复杂化。我们描述了一名患有多种合并症的患者,该患者接受奥马珠单抗治疗成功,并建议将奥马珠单抗作为BP的一种良好替代疗法,以预防一般状况较差的老年患者发生与治疗相关的并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d245/9314756/520ae7557185/CCID-15-1391-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d245/9314756/44266455941b/CCID-15-1391-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d245/9314756/520ae7557185/CCID-15-1391-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d245/9314756/44266455941b/CCID-15-1391-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d245/9314756/520ae7557185/CCID-15-1391-g0002.jpg

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Case Report: Omalizumab Successfully Treated Recalcitrant Bullous Pemphigoid in an Elderly Patient with Multiple Comorbidities.病例报告:奥马珠单抗成功治疗一名患有多种合并症的老年患者的顽固性大疱性类天疱疮。
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引用本文的文献

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本文引用的文献

1
Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of Efficacy and Safety.奥马珠单抗治疗大疱性类天疱疮:疗效和安全性的系统评价。
J Cutan Med Surg. 2022 Jul-Aug;26(4):404-413. doi: 10.1177/12034754221089267. Epub 2022 Apr 4.
2
Global incidence and prevalence of bullous pemphigoid: A systematic review and meta-analysis.全球大疱性类天疱疮的发病率和患病率:系统评价和荟萃分析。
J Cosmet Dermatol. 2022 Oct;21(10):4818-4835. doi: 10.1111/jocd.14797. Epub 2022 Feb 1.
3
Risk of All-Cause Mortality, Cardiovascular Disease Mortality, and Cancer Mortality in Patients With Bullous Pemphigoid.
大疱性类天疱疮患者的全因死亡率、心血管疾病死亡率和癌症死亡率风险。
JAMA Dermatol. 2022 Feb 1;158(2):167-175. doi: 10.1001/jamadermatol.2021.5125.
4
Efficacy and Safety of Dupilumab in Moderate-to-Severe Bullous Pemphigoid.度普利尤单抗治疗中重度大疱性类天疱疮的疗效和安全性。
Front Immunol. 2021 Oct 14;12:738907. doi: 10.3389/fimmu.2021.738907. eCollection 2021.
5
The impact of diabetes mellitus on medical complication and mortality rates among inpatients with bullous pemphigoid.糖尿病对大疱性类天疱疮住院患者的医疗并发症和死亡率的影响。
Ir J Med Sci. 2022 Aug;191(4):1669-1675. doi: 10.1007/s11845-021-02726-9. Epub 2021 Aug 16.
6
Mortality and clinical response of patients with bullous pemphigoid treated with rituximab.使用利妥昔单抗治疗的大疱性类天疱疮患者的死亡率和临床反应
Br J Dermatol. 2021 Jul;185(1):210-212. doi: 10.1111/bjd.19890. Epub 2021 Mar 31.
7
Association of bullous pemphigoid and comorbid health conditions: a case-control study.大疱性类天疱疮与合并症的相关性:一项病例对照研究。
Arch Dermatol Res. 2021 Jul;313(5):327-332. doi: 10.1007/s00403-020-02100-2. Epub 2020 Jul 10.
8
Effects of Omalizumab on FcεRI and IgE Expression in Lesional Skin of Bullous Pemphigoid.奥马珠单抗对大疱性类天疱疮皮损皮肤中 FcεRI 和 IgE 表达的影响。
Front Immunol. 2019 Aug 14;10:1919. doi: 10.3389/fimmu.2019.01919. eCollection 2019.
9
Rituximab and Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of the Literature.利妥昔单抗和奥马珠单抗治疗大疱性类天疱疮:文献系统评价。
Am J Clin Dermatol. 2019 Apr;20(2):209-216. doi: 10.1007/s40257-018-0401-6.
10
Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation.大疱性类天疱疮外周血嗜酸性粒细胞增多症:患病率及其对临床表现的影响。
Br J Dermatol. 2018 Nov;179(5):1141-1147. doi: 10.1111/bjd.16679. Epub 2018 Jul 4.