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在 SARS-CoV-2 爆发的背景下,选择和鉴定生物受体以开发基于纳米颗粒的侧向流动免疫分析。

Selection and characterisation of bioreceptors to develop nanoparticle-based lateral-flow immunoassays in the context of the SARS-CoV-2 outbreak.

机构信息

Nanobioelectronics & Biosensors Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST, Campus UAB, 08193, Bellaterra, Barcelona, Spain.

ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic (Department of International Health), Universitat de Barcelona, Barcelona, Spain.

出版信息

Lab Chip. 2022 Aug 9;22(16):2938-2943. doi: 10.1039/d2lc00486k.

Abstract

This manuscript aims at raising the attention of the scientific community to the need for better characterised bioreceptors for fast development of point-of-care diagnostic devices able to support mass frequency testing. Particularly, we present the difficulties encountered in finding suitable antibodies for the development of a lateral flow assay for detecting the nucleoprotein of SARS-CoV-2.

摘要

本文旨在引起科学界的关注,需要更好地表征生物受体,以快速开发能够支持大规模频率检测的即时诊断设备。特别是,我们介绍了在开发用于检测 SARS-CoV-2 核蛋白的侧向流动测定中寻找合适抗体时遇到的困难。

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