酸促进的吲哚与芳基炔烃的分子内和分子间[2+2]环加成反应，以获得环丁烯稠合的吲哚啉。
Acid-promoted intra- and intermolecular [2+2] cycloaddition of indoles to aryl alkynes to access cyclobutene-fused indolines.
机构信息
Xiangya School of Pharmaceutical Science, Central South University, Changsha, Hunan, 410013, P. R. China.
Hunan Key laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, Hunan, 410013, P. R. China.
出版信息
Chem Commun (Camb). 2022 Aug 16;58(66):9270-9273. doi: 10.1039/d2cc02840a.
Herein, we have reported the first example of both intra- and intermolecular [2+2] cycloaddition of the electron-rich indoles and unactivated aryl alkynes promoted by the combination of Fe(NO) and HNO, which highlights efficient and selective access to several different types of functionalized cyclobutene-fused indolines from readily available starting materials with cheap catalysts and simple operations.
在此，我们报道了首例富电子吲哚分子内和分子间[2+2]环加成反应以及由 Fe(NO)和 HNO 共同促进的未活化芳基炔烃的[2+2]环加成反应，这为从易得的起始原料中高效、高选择性地获得多种不同类型的功能化环丁烯稠合吲哚啉提供了一条途径，使用的催化剂廉价，操作简单。
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