• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[以昔康类为例,考虑临床和药理学特征,非甾体抗炎药个体化选择的可能性]

[Possibilities of individual choice of NSAIDs on the example of the oxicam class, taking into account clinical and pharmacological characteristics].

作者信息

Putilina M V, Teplova N V

机构信息

Pirogov Russian National Research Medical Univesity, Moscow, Russia.

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(7):36-41. doi: 10.17116/jnevro202212207136.

DOI:10.17116/jnevro202212207136
PMID:35904290
Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are traditionally used to relieve pain syndromes. The class of NSAIDs includes oxicams (meloxicam, tenoxicam, lornoxicam) - drugs with pronounced analgesic and anti-inflammatory effects. Oxicams have common properties of the class, but at the same time, due to structural differences from all other NSAIDs, they differ in a number of clinical and pharmacological characteristics, knowledge of which will help to individualize the choice of the drug.

摘要

非甾体抗炎药(NSAIDs)传统上用于缓解疼痛综合征。NSAIDs类药物包括昔康类(美洛昔康、替诺昔康、氯诺昔康)——具有显著镇痛和抗炎作用的药物。昔康类药物具有该类药物的共同特性,但同时,由于其与所有其他NSAIDs在结构上存在差异,它们在一些临床和药理学特征方面有所不同,了解这些特征将有助于个体化选择药物。

相似文献

1
[Possibilities of individual choice of NSAIDs on the example of the oxicam class, taking into account clinical and pharmacological characteristics].[以昔康类为例,考虑临床和药理学特征,非甾体抗炎药个体化选择的可能性]
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(7):36-41. doi: 10.17116/jnevro202212207136.
2
Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond.昔布类,非甾体类抗炎药及其以外的药物。
IUBMB Life. 2014 Dec;66(12):803-11. doi: 10.1002/iub.1334. Epub 2014 Dec 23.
3
Enzymatic probing of model lipid membranes: phospholipase A2 activity toward monolayers modified by oxicam NSAIDs.通过模型脂质膜的酶促探测:过氧羧酸类 NSAIDs 修饰的单层中磷脂酶 A2 的活性。
J Phys Chem B. 2011 Jul 28;115(29):9290-8. doi: 10.1021/jp202716k. Epub 2011 Jul 7.
4
Lornoxicam. A review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions.氯诺昔康。对其在疼痛和炎症性疾病管理中的药理学及治疗潜力的综述。
Drugs. 1996 Apr;51(4):639-57. doi: 10.2165/00003495-199651040-00008.
5
Photophysical studies of oxicam group of NSAIDs: piroxicam, meloxicam and tenoxicam.非甾体抗炎药(NSAIDs)昔康类药物的光物理研究:吡罗昔康、美洛昔康和替诺昔康。
Spectrochim Acta A Mol Biomol Spectrosc. 2003 Apr;59(6):1213-22. doi: 10.1016/s1386-1425(02)00300-1.
6
[Cytogenetic studies of human lymphocytes under the influence of oxicams].
Z Rheumatol. 1990 Mar-Apr;49(2):77-81.
7
Modulating Properties of Piroxicam, Meloxicam and Oxicam Analogues against Macrophage-Associated Chemokines in Colorectal Cancer.吡罗昔康、美洛昔康和奥昔康类似物对结直肠癌中巨噬细胞相关趋化因子的调节作用。
Molecules. 2021 Dec 5;26(23):7375. doi: 10.3390/molecules26237375.
8
The reactions of oxicam and sulfoanilide non steroidal anti-inflammatory drugs with hypochlorous acid: determination of the rate constants with an assay based on the competition with para-aminobenzoic acid chlorination and identification of some oxidation products.昔康类和磺酰苯胺类非甾体抗炎药与次氯酸的反应:基于与对氨基苯甲酸氯化反应竞争的测定法测定速率常数及某些氧化产物的鉴定
Free Radic Res. 2004 Mar;38(3):251-8. doi: 10.1080/10715760310001659404.
9
Differentiating oxicam nonsteroidal anti-inflammatory drugs in phosphoglyceride monolayers.在磷酸甘油酯单层中区分氧杂蒽酮类非甾体抗炎药。
Langmuir. 2010 Mar 2;26(5):3485-92. doi: 10.1021/la903052t.
10
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.昔布类药物通过一个双水分子介导氢键网络以新颖的模式与环氧化酶活性位点结合。
J Biol Chem. 2014 Mar 7;289(10):6799-6808. doi: 10.1074/jbc.M113.517987. Epub 2014 Jan 14.