基因多态性DRD3 rs6280、COMT rs4680和HTR2A rs7322347与精神分裂症的关联
[Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia].
作者信息
Sofronov A G, Dobrovolskaya A E, Morozova A Yu, Gorina E A, Kolchev S A, Gvozdetckii A N
机构信息
Mechnikov North-Western State Medical University, St. Petersburg, Russia.
Skvortsov-Stepanov St. Petersburg Psychiatric Hospital No 3, St. Petersburg, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(7):115-120. doi: 10.17116/jnevro2022122071115.
OBJECTIVE
To check the association of genetic polymorphisms rs6280 of the DRD3 gene, rs4680 of the gene, rs7322347 of the gene with schizophrenia.
MATERIAL AND METHODS
The sample included 300 inpatients with paranoid schizophrenia. Inclusion criteria: age 18-50 years, established diagnosis «Schizophrenia, paranoid form», duration of psychiatric disorders not less than 5 years. The healthy control group consisted of 290 subjects. The association between polymorphisms and the study groups was assessed by logistic regression.
RESULTS
The CC genotype of the rs6280 polymorphism is associated with schizophrenia (OR 3.37 (1.50; 8.03)). The TT genotype of the rs7322347 polymorphism is associated with controls (OR 1.83 (1.25; 2.68)).
CONCLUSION
These analyses confirmed the hypothesis that the genetic polymorphisms rs7322347 of the gene (=0.006) and rs6280 of the gene (=0.004) were associated with the disease. The hypothesis of an association of the rs4680 polymorphism of the gene could not be confirmed.
目的
检测DRD3基因的rs6280多态性、某基因的rs4680多态性、某基因的rs7322347多态性与精神分裂症的关联。
材料与方法
样本包括300例偏执型精神分裂症住院患者。纳入标准：年龄18 - 50岁，确诊为“精神分裂症，偏执型”，精神障碍病程不少于5年。健康对照组由290名受试者组成。通过逻辑回归评估多态性与研究组之间的关联。
结果
rs6280多态性的CC基因型与精神分裂症相关（比值比3.37（1.50；8.03））。rs7322347多态性的TT基因型与对照组相关（比值比1.83（1.25；2.68））。
结论
这些分析证实了以下假设，即某基因的rs7322347多态性（P = 0.006）和某基因的rs6280多态性（P = 0.004）与该疾病相关。某基因的rs4680多态性的关联假设未得到证实。
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